Publications by authors named "Laura Palomino"
Article Synopsis
- The study assessed how being overweight or obese affects treatment response and relapse rates in children with inflammatory bowel disease (IBD) undergoing anti-TNF therapy.
- Conducted across 22 centers in 14 countries, it involved 637 children, with a comparison between those who were overweight/obese and those of normal weight.
- Findings showed no difference in loss of response to treatment initially, but overweight/obese children had higher relapse rates by the end of follow-up, indicating a potential long-term risk associated with their weight status.
Article Synopsis
- Pediatric inflammatory bowel disease (PIBD) significantly affects family dynamics and caregiver work productivity, leading to economic strain on families.
- A multicenter study involving 370 parents of PIBD patients aged 10-18 revealed a 22.9% unemployment rate among caregivers, notably higher for mothers at 30.7%, with absenteeism and presenteeism further complicating work situations.
- The research highlights the need for targeted support and policy improvements to reduce the socioeconomic impact on families caring for children with PIBD.
Cross-cultural adaptation and validation of Work Productivity and Activity Impairment questionnaires for caregivers of patients with pediatric inflammatory bowel disease in Spain. A multicenter study.
Arch Argent Pediatr
December 2024
Article Synopsis
- The WPAI-UC/CD-Caregiver questionnaires evaluate how ulcerative colitis (UC) and Crohn's disease (CD) affect the work life and daily activities of caregivers in Spain.
- The study involved translating the questionnaires, getting feedback from experts and families, and validating them using data from 370 patients and their caregivers, ensuring they are effective and quick to complete.
- Results showed good reliability and validity of the Spanish versions of the questionnaires, making them suitable for use by families of children with inflammatory bowel disease (IBD).
Unlabelled: IMPACT-III and IMPACT-III-P are health-related quality of life (HRQoL) questionnaires for patients with pediatric inflammatory bowel disease (p-IBD) and their parents/caregivers. We aimed to perform a transcultural adaptation and validation for the Spanish context. Translation, back-translation, and evaluation of the questionnaires were performed by an expert committee and 12 p-IBD families.
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- This study focuses on how gene expression changes may affect pediatric patients with inflammatory bowel diseases (IBDs) in their response to anti-TNF treatments like infliximab and adalimumab.
- Researchers analyzed blood samples from 24 patients to identify genes that could predict early treatment responses, discovering 102 differentially expressed genes.
- Key findings included four validated genes (CEACAM8, LCN2, LTF2, and PRTN3) that showed increased expression in responders, highlighting their potential role in treatment effectiveness and involvement in immune responses.
(1) Background: Transition is a planned movement of paediatric patients to adult healthcare systems, and its implementation is not yet established in all inflammatory bowel disease (IBD) units. The aim of the study was to evaluate the impact of transition on IBD outcomes. (2) Methods: Multicentre, retrospective and observational study of IBD paediatric patients transferred to an adult IBD unit between 2017-2020.
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- * A total of 340 pediatric patients treated with infliximab or adalimumab were genotyped for 9 specific genetic variants, revealing that certain variants are linked to poorer long-term treatment outcomes.
- * Identifying these genetic markers could help tailor anti-TNF therapy for children, allowing healthcare providers to better predict which patients are likely to benefit in the long run, pending further validation.
Article Synopsis
- The study investigates the genetic variants rs2395185 and rs2097432 in HLA genes and their effect on the long-term efficacy of anti-TNF treatments in children with inflammatory bowel disease (IBD).
- Researchers conducted an analysis on 340 pediatric IBD patients from Spanish hospitals, using statistical methods to assess the impact of these genetic polymorphisms on treatment outcomes.
- Results showed that specific alleles (homozygous G for rs2395185 and C for rs2097432) were linked to a reduced long-term response to anti-TNF drugs, highlighting a difference in response between children and adults with Crohn's disease treated with infliximab.
Objective: These days, the gold standard procedure for otosclerosis treatment is stapes surgery. The endoscopic approach of the procedure is gaining popularity as endoscopic ear surgery develops across the globe. The main objective of this study is to gather and compile well-documented and reliable data regarding surgical outcomes for the endoscopic approach to stapes surgery up to this date.
View Article and Find Full Text PDF[Results in the surgical treatment of giant acoustic neuromas].
Acta Otorrinolaringol Esp
September 2012
Introduction And Objectives: To compare the results obtained in the resection of 21 giant vestibular schwannomas via retrosigmoid (RS) and combined retrosigmoid/translabyrinthine (RS/TL) approaches with respect to intra- and postoperative complications, facial nerve preservation and postsurgical sequelae.
Methods: This was a retrospective study of 21 patients who underwent a resection of a giant vestibular neuroma according to the Tos & Thomsen Scale (greater than or equal to 4 centimetres) in a tertiary care centre in the period between 2000 and 2008. We present the most significant characteristics of the series studied and the analysis of the advantages and inconveniences of each approach.