Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care.

Background: Hotspot mutations of the oncogenes BRAF and NRAS are the most common genetic alterations in cutaneous melanoma. Specific inhibitors of BRAF and MEK have shown significant survival benefits in large phase III trials. However, the prognostic significance of BRAF and NRAS mutations outside of clinical trials remains unclear.

Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma.

Background: Mucosal melanoma (MM) is a rare but diverse cancer entity. Prognostic factors are not well established for Caucasians with MM.

Patients And Methods: We analysed the disease course of 444 patients from 15 German skin cancer centres.