Predicting Diagnostic Conversion From Major Depressive Disorder to Bipolar Disorder: An EHR Based Study From Colombia.

Objectives: Most bipolar disorder (BD) patients initially present with depressive symptoms, resulting in a delayed diagnosis of BD and poor clinical outcomes. This study aims to identify features predictive of the conversion from Major Depressive Disorder (MDD) to BD by leveraging electronic health record (EHR) data from the Clínica San Juan de Dios Manizales in Colombia.

Methods: We employed a multivariable Cox regression model to identify important predictors of conversion from MDD to BD.

Predicting diagnostic conversion from major depressive disorder to bipolar disorder: an EHR based study from Colombia.

Bipolar Disorder (BD) is a severe and chronic disorder characterized by recurrent episodes of depression, mania, and/or hypomania. Most BD patients initially present with depressive symptoms, resulting in a delayed diagnosis of BD and poor clinical outcomes. This study leverages electronic health record (EHR) data from the Clínica San Juan de Dios Manizales in Colombia to identify features predictive of the transition from Major Depressive Disorder (MDD) to BD.

Two New Compounds Containing Pyridinone or Triazine Heterocycles Have Antifungal Properties against .

Candidiasis, caused by the opportunistic yeast , is the most common fungal infection today. Resistance of to current antifungal drugs has emerged over the past decade leading to the need for novel antifungal agents. Our aim was to select new antifungal compounds by library-screening methods and to assess their antifungal effects against .

Relationships between central and peripheral corneal thickness in different degrees of myopia.

Purpose: To analyze the relationship between the central corneal thickness (CCT) and mid-peripheral corneal thickness (PCT) with the degree of myopia [axial length (AL) and spherical equivalent refractive error (SE)].

Methods: 175 right myopic eyes from 175 patients were divided according to the degree of SE: group #1 (n=76, <6.00 D), group #2 (n=72, between 6.

Culture and alcohol use: historical and sociocultural themes from 75 years of alcohol research.

Objective: For the period of almost 75 years, we examined the literature for studies regarding the influences of culture on alcohol use and misuse.

Method: This review is a chronology of research articles published from 1940 to 2013. From a structured literature search with select criteria, 38 articles were identified and 34 reviewed.

Basal values, intra-day and inter-day variations in tear film osmolarity and tear fluorescein clearance.

Purpose: The aim of this study was to determine the normal inter-day and intra-day variations in tear film osmolarity and the tear fluorescein clearance test (T-FCT) in healthy subjects.

Methods: Tear samples from 24 young, healthy adults were collected from 11:00 AM to 1:00 PM (midday) and 5:00 PM to 7:00 PM (evening) on three non-consecutive days. Tear osmolarity measurement and the T-FCT were performed to assess the basal values and inter-day and intra-day variations of the test results.

Depressed skull fracture by a three-pin head holder: a case illustration.

Unlabelled: BACKGROUND AND CASE REPORT: Many surgical procedures require a rigid immobilization of the patients' head, which is usually achieved by using a pin-type head holder. We briefly illustrate the case of a 4-year-old girl who sustained a depressed skull fracture by penetration of a pin of the head holder. The fracture was noted at the end of the surgery performed for treatment of a cerebellar astrocytoma and was managed conservatively.