Publications by authors named "Laura Meleady"
As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules. Histone acetylation is an activating transcriptional mark that regulates inflammatory gene expression. Inhibition of histone deacetylase 3 (Hdac3) has been utilized in pre-clinical models of depression, stroke, and spinal cord injury to improve recovery following injury, but the molecular mechanisms underlying Hdac3's regulation of inflammatory gene expression in microglia is not well understood.
View Article and Find Full Text PDFProgression to Anti-TNF Treatment in Very Early Onset Inflammatory Bowel Disease Patients.
J Pediatr Gastroenterol Nutr
October 2022
Article Synopsis
- The study investigates long-term outcomes and the timing of anti-tumor necrosis factor (anti-TNF) treatments in young patients with very early onset inflammatory bowel disease (VEOIBD), specifically diagnosed under 6 years old.
- A total of 89 VEOIBD patients were reviewed, with findings indicating that 39.5% initiated anti-TNF treatment, and the disease's severity significantly influenced the progression to treatment.
- Notably, a higher response rate was observed in patients, potentially linked to increased infliximab dosing and shorter infusion intervals compared to standard practices.
Background And Aim: While weight gain during infliximab therapy in inflammatory bowel disease (IBD) is common, there has been limited research evaluating its impact on infliximab efficacy.
Methods: Primary aims of this study were to determine the frequency of excess weight gain (body mass index [BMI] > 25 kg/m) in children with IBD on maintenance infliximab and evaluate the impact on infliximab dosing, serum trough levels, and treatment failure. Secondary aims were to determine differences in weight gain, treatment characteristics, and clinical/biochemical variables between patients with therapeutic and subtherapeutic maintenance therapy trough levels.