Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment.

Olfactory dysfunction and atrophy of olfactory brain regions are observed early in mild cognitive impairment and Alzheimer disease. Despite substantial evidence showing neuroprotective effects in MCI/AD with treatment of docosahexaenoic acid (DHA), an omega-3 fatty acid, few studies have assessed DHA and its effects on the olfactory system deficits. We therefore performed structural (MRI), functional (olfactory behavior, novel object recognition), and molecular (markers of apoptosis and inflammation) assessments of APOE4 and wild-type mice ± DHA treatment at 3, 6, and 12 months of age.

[Increased screen hours are associated with low school performance].

Objective: To analyze whether screen time is related to lower academic performance in second-cycle students and to determine differences by sex.

Subjects And Method: Analytical, retrospective, and cross-sectional research. 733 students from the 5th to 8th year of public schools participating in the study "school health and performance survey in the Biobío province 2018" were recruited.