Publications by authors named "Laura M de Bes-Roeleveld"
Article Synopsis
- The study focuses on how the age of Plasmodium falciparum sporozoites (SPZ) in mosquitoes affects their infectivity and the immune response they trigger in humans, specifically examining SPZ that are 14, 17, and 20 days old.*
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- Results indicated that while the number and viability of SPZ did not change with age, their motility decreased significantly over time, and the infectivity of SPZ dropped notably from 14 to 20 days.*
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- Additionally, immune responses showed that macrophages were more effective at taking up SPZ at 14 days, resulting in higher expression of inflammatory markers compared to those that were 20 days old.*
EBioMedicine
November 2023
Article Synopsis
- - A new controlled human infection model for schistosomiasis (CHI-S) using female-only Schistosoma mansoni cercariae was developed to improve vaccine research and understand early immune responses.
- - Thirteen healthy participants were exposed to either 10 or 20 female cercariae, resulting in most experiencing rash or mild symptoms, with some showing detectable infection despite receiving praziquantel treatment.
- - The study found that female infections display similar symptoms and immune responses as male infections but show greater resistance to praziquantel, suggesting challenges for future research and disease control efforts.
