Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [Ga]MHLL1.

Myocardial infarction (MI) evokes an organized remodeling process characterized by the activation and transdifferentiation of quiescent cardiac fibroblasts to generate a stable collagen rich scar. Early fibroblast activation may be amenable to targeted therapy, but is challenging to identify . We aimed to non-invasively image active fibrosis by targeting the fibroblast activation protein (FAP) expressed by activated (myo)fibroblasts, using a novel positron emission tomography (PET) radioligand [Ga]MHLL1 after acute MI.

Comparison Study of Two Differently Clicked F-Folates-Lipophilicity Plays a Key Role.

Within the last decade, several folate-based radiopharmaceuticals for Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been evaluated; however, there is still a lack of suitable F-folates for clinical PET imaging. Herein, we report the synthesis and evaluation of two novel F-folates employing strain-promoted and copper-catalyzed click chemistry. Furthermore, the influence of both click-methods on lipophilicity and pharmacokinetics of the F-folates was investigated.