Biguanide-transition metals complexes as potential drug for hyperglycemia treatment.

Coordination compounds of Cu(ii), Ni(ii), Co(ii), and Zn(ii) with a type of biguanide (known commercially as metformin) have been synthesized and characterized using spectroscopic techniques (FT-IR, UV/VIS), X-ray diffraction techniques and thermal analysis. For all compounds, single crystals were obtained for single-crystal X-ray diffraction. For the first time, an octahedral cobalt compound with the formula [Co(CHN)]Cl·2HO that crystallizes in the monoclinic space group 2/ with one molecule in the asymmetric unit has been obtained.