Publications by authors named "Laura M Mira"
Antimicrobial peptides designed by computational analysis of proteomes.
Antonie Van Leeuwenhoek
March 2024
Article Synopsis
- Antimicrobial peptides (AMPs) offer a promising solution to combat antibiotic resistance, and a computational approach was used to identify and modify peptide sequences from various organisms to enhance their antimicrobial properties.
- Out of 150,450 analyzed proteins from multiple sources, 18 modified peptides were tested, resulting in 14 demonstrating antimicrobial effects against several bacterial species and yeast, with some also showing activity against cancer cell lines.
- Key findings indicate that the most effective AMPs damage bacterial cell membranes, and the study highlights the success of integrating bioinformatics and rational modifications to uncover powerful AMPs hidden in proteins.