Publications by authors named "Laura M Meyer"
The selective autophagic degradation of mitochondria via mitophagy is essential for preserving mitochondrial homeostasis and, thereby, disease maintenance and progression in acute myeloid leukemia (AML). Mitophagy is orchestrated by a variety of mitophagy receptors whose interplay is not well understood. Here, we established a pairwise multiplexed CRISPR screen targeting mitophagy receptors to elucidate redundancies and gain a deeper understanding of the functional interactome governing mitophagy in AML.
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- In about 25% of acute myeloid leukemia (AML) patients, a genetic change called FLT3 internal tandem duplications (ITD) makes their leukemia worse and harder to treat.
- Some common treatments called FLT3 inhibitors (FLT3i) often don’t work well because the cancer cells adapt and resist the therapy, making it a big challenge for doctors.
- Researchers found that a process called autophagy helps these leukemia cells resist treatment, and combining FLT3 inhibitors with autophagy blockers made the treatment much more effective in experiments on lab cells and mice.