Publications by authors named "Laura M Donahue"

Introduction: Surgical cap attire plays an important role in creating a safe and sterile environment in procedural suites, thus the choice of reusable versus disposable caps has become an issue of much debate. Given the lack of evidence for differences in surgical site infection (SSI) risk between the two, selecting the cap option with a lower carbon footprint may reduce the environmental impact of surgical procedures. However, many institutions continue to recommend the use of disposable bouffant caps.

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Background: Over the last decade, medical student residency applicants have shown a substantial increase in the number of interviews attended, which is associated with a significant increase in travel. The carbon footprint associated with residency interviews has not been well documented prior to this investigation, and is a critical issue related to climate health.

Objective: The purpose of this study is to document the carbon footprint associated with travel to residency interviews of the applicants from a single institution.

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Background: Healthcare systems in the United States have increasingly turned toward the use of disposable medical equipment in an attempt to save time, lower costs, and reduce the transmission of infections. However, the use of disposable instruments is associated with increased solid waste production and may have negative impacts on the environment, such as increased greenhouse gas emissions.

Objective: The purpose of this study was to inform this discussion; we applied life cycle assessment methods to evaluate the carbon footprints of 3 vaginal specula: a single-use acrylic model and 2 reusable stainless steel models.

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Article Synopsis
  • Ret is a receptor tyrosine kinase that, when activated by GDNF, undergoes rapid polyubiquitination and degradation, which varies based on its isoform (Ret51 vs. Ret9).
  • The degradation of Ret51 involves a complex formed by the adaptor protein CD2AP and the E3-ligase Cbl-3/c, where the latter is identified as a key player in this process.
  • Specific domains within CD2AP and Cbl-3/c are crucial for enhancing ubiquitination of Ret51, while feedback mechanisms exist since activated Ret can degrade CD2AP but not Cbl-3/c.
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