Regulation of GABAARs by phosphorylation.

γ-Aminobutyric acid type A receptors (GABAARs) are the principal mediators of fast synaptic inhibition in the brain as well as the low persistent extrasynaptic inhibition, both of which are fundamental to proper brain function. Thus unsurprisingly, deficits in GABAARs are implicated in a number of neurological disorders and diseases. The complexity of GABAAR regulation is determined not only by the heterogeneity of these receptors but also by its posttranslational modifications, the foremost, and best characterized of which is phosphorylation.

Perceptual learning of co-articulation in speech.

Four experiments investigated the novel issue of learning to accommodate the coarticulated nature of speech. Experiment 1 established a co-articulatory mismatch effect for a set of vowel-consonant (VC) syllables (reaction times were faster for co-articulation matching than for mismatching stimuli). A rhyme judgment training task on words (Experiment 2) or VC stimuli (Experiment 3) with mismatching information was followed by a phoneme monitoring task on a set of VC stimuli; training and test stimuli contained physically identical (same condition) or new (different condition) mismatching coarticulatory information (along with a set containing matching coarticulatory information).