Diabetes mellitus is not a risk factor for osteoarthritis.

Background: Association between diabetes mellitus (DM) and risk of osteoarthritis (OA) can be confounded by body mass index (BMI), a strong risk factor for both conditions. We evaluate the association between DM or hyperglycaemia with OA using systematic review and meta-analysis.

Methods: We searched PubMed and Web of Science databases in English for studies that gave information on the association between DM and OA.

Colchicine--Update on mechanisms of action and therapeutic uses.

Objectives: To review the literature and provide an update on the mechanisms of action and therapeutic uses of oral colchicine in arthritis and inflammatory conditions.

Methods: We performed PubMed database searches through June 2014 for relevant studies in the English literature published since the last update of colchicine in 2008. Searches encompassed colchicine mechanisms of action and clinical applications in medical conditions.