Publications by authors named "Laura Leticia Valdez-Velazquez"
Cardiac alterations induced by Heloderma horridum horridum venom in rats: An experimental study with ECG analysis using a linear regression algorithm.
Toxicon
October 2024
Article Synopsis
- Envenomation by Heloderma horridum, a lizard species, can cause notable physiological changes, particularly in heart function, as demonstrated in tests on Wistar rats.
- The study utilized a specialized computational linear regression algorithm to enhance the analysis of ECG data, achieving a 97.5% efficiency in detecting key heartwave components.
- Despite significant electrocardiographic changes and arrhythmias observed, there were no major signs of physical or inflammatory damage to the heart tissue, indicating that the venom primarily affects heart conduction rather than causing direct myocardial damage.
Unveiling the Protein Components of the Secretory-Venom Gland and Venom of the Scorpion (Buthidae) through Omic Technologies.
Toxins (Basel)
August 2023
Article Synopsis
- A newly discovered "striped scorpion" species from Mexico is toxic to mammals and has potential therapeutic and biotechnological uses.
- The study involved determining the lethal dose for mice and analyzing its secretory gland transcriptome and venom proteome using high-throughput sequencing and mass spectrometry.
- The research identified 244 complete transcripts related to toxins and 70 venom components, making it the most comprehensive analysis of scorpion venom to date and providing new insights into venom biology.
Scorpions are a group of arthropods that strike fear in many people due to their severe medical symptoms, even death, caused by their venomous stings. Even so, not all scorpion species contain harmful venoms against humans but still have valuable bioactive molecules, which could be used in developing new pharmaceutical leads for treating important diseases. This work conducted a comprehensive analysis of the venom from the scorpion Thorellius intrepidus.
View Article and Find Full Text PDFSkin secretions of toads are a complex mixture of molecules. The substances secreted comprise more than 80 different compounds that show diverse pharmacological activities. The compounds secreted through skin pores and parotid glands are of particular interest because they help toads to endure in habitats full of pathogenic microbes, i.
View Article and Find Full Text PDFArticle Synopsis
- The Helodermatidae family of lizards includes two main species known for their venomous secretions: Heloderma horridum horridum and Heloderma suspectum suspectum.
- Researchers used RNA sequencing (RNA-seq) to analyze the venom glands of H. horridum horridum, discovering over 114,000 transcripts with 199 annotated based on previous studies.
- The study identified various highly expressed proteins in the venom, including exendins, defensins, and serine protease inhibitors, which could enhance our understanding of their venom and its biological effects.
As part of an ongoing survey of scorpion diversity in Colima, Mexico, the isolated mountain Cerro Grande, part of the Biosphere Reserve Sierra de Manantlán, was investigated. Centruroides possanii sp. nov.
View Article and Find Full Text PDFAn association between thrombophilic genes and obstetric conditions with early pregnancy termination has been previously proposed. In the present study we attempted to evaluate the possible association between thrombophilic genetic polymorphisms and habitual abortion (HA). Samples from two groups of volunteers were analyzed.
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