Publications by authors named "Laura Lee Masters"
Article Synopsis
- The study successfully cloned a low-passage strain of murine cytomegalovirus (MCMV) known as G4 as a bacterial artificial chromosome (BAC), enabling better manipulation and understanding of the virus.
- Unlike lab strains, G4 can replicate effectively in C57BL/6 mice due to a specific gene modification (m157) that alters its interaction with natural killer (NK) cells.
- Through next-generation sequencing, researchers discovered a mutation affecting salivary gland tropism and identified a novel spliced gene (sgg1.1) whose restoration improved the virus's ability to infect salivary glands, offering new insights into the virus's biology.
