Antioxidant Behavioural Phenotype in the Gene Knock-Out Mouse.

Mitochondrial dysfunction is strongly associated with autism spectrum disorder (ASD) and the gene is linked to autism inheritance. However, the biological basis of this linkage is unknown notwithstanding independent reports of oxidative stress in association with both IMMP2L and ASD. To better understand association with behaviour, we developed the knockout (KO) mouse model which is devoid of Immp2l peptidase activity.