Expression profiling across wild and cultivated tomatoes supports the relevance of early miR482/2118 suppression for resistance.

Plants possess a battery of specific pathogen resistance ()genes. Precise gene regulation is important in the presence and absence of a pathogen. Recently, a microRNA family, miR482/2118, was shown to regulate the expression of a major class of genes nucleotide-binding site leucine-rich repeats ().

Evolutionarily Dynamic, but Robust, Targeting of Resistance Genes by the miR482/2118 Gene Family in the Solanaceae.

Plants are exposed to pathogens around the clock. A common resistance response in plants upon pathogen detection is localized cell death. Given the irreversible nature of this response, multiple layers of negative regulation are present to prevent the untimely or misexpression of resistance genes.