Lymphotoxin-beta receptor signalling regulates cytokine expression via TRIM30α in a TRAF3-dependent manner.

Our earlier studies indicated that activation of the lymphotoxin beta receptor (LTβR) by T cell derived LTα(1)β(2) regulates inflammatory cytokine expression. While characterizing the cellular and molecular mechanisms responsible for the down regulation of the inflammatory reaction after LTβR stimulation we were able to identify the specific induction of TRIM30α expression as a result of LTβR signalling in mouse macrophages. Furthermore, we could demonstrate that LTβR activation in these cells results in the down regulation of pro-inflammatory cytokine (e.

Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome.

Nevus sebaceous is a common congenital cutaneous malformation. Affected individuals may develop benign and malignant secondary tumors in the nevi during life. Schimmelpenning syndrome is characterized by the association of nevus sebaceous with extracutaneous abnormalities.

E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurin.

Escape from the host immune system is essential for intracellular pathogens. The adenoviral protein E3-14.7K (14.