Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum.

Arterial Calcification due to Deficiency of CD73 (ACDC) results from mutations in the NT5E gene encoding the 5' exonucleotidase, CD73. We now describe the third familial case of ACDC, including radiological and histopathological details of the arterial calcifications. The medial lesions involve the entire circumference of the elastic lamina, in contrast to the intimal plaque-like disease of atherosclerosis.

Heparin-induced thrombocytopenia and graft thrombosis following endovascular aneurysm repair.

Purpose: To report a case of heparin-induced thrombocytopenia (HIT) complicated by stent-graft thrombosis.

Case Report: An 82-year-old woman underwent endovascular aortic aneurysm repair using a Zenith stent-graft. She returned 2 weeks later with an occluded graft limb, large quantities of thrombus lining the remainder of the stent-graft, thrombocytopenia, and antiplatelet antibodies.

Successful bilateral transaortic renal endarterectomy after failed renal artery angioplasty and stenting: a case report.

Restenosis after renal angioplasty and stenting is usually treated with repeat angioplasty or surgery. Because development of substantial postangioplasty periarterial fibrosis is thought to preclude transaortic endarterectomy, renal artery bypass grafting has been the operation of choice in this setting. This report describes successful bilateral transaortic renal thromboendarterectomy undertaken for the treatment of restenosis after percutaneous angioplasty and stenting for renovascular hypertension caused by bilateral renal artery nonostial stenosis.