Framework for fiscal impact analysis of managing initial caries lesions with noninvasive therapies.

Background: Evidence-based noninvasive caries therapies for initial caries lesions are available in the United States. Fundamental differences between noninvasive therapies and the traditional surgical dental approach warrant a study of the financial scalability.

Methods: The financial costs and benefits of fee-for-service clinics and payors were compared across 11 scenarios simulating the treatment of 1,000 initial caries lesions during a 3-year period.

Systematic review and meta-analysis on the effect of self-assembling peptide P-4 on arrest, cavitation, and progression of initial caries lesions.

Background: Simple noninvasive evidence-based interventions for caries are needed to overcome limitations in the restorative paradigm. The self-assembling peptide P-4 is a noninvasive intervention that regenerates enamel in initial caries lesions.

Studies Reviewed: The authors conducted a systematic review and meta-analysis on the effectiveness of the P-4 products Curodont Repair (Credentis; now manufactured by vVARDIS) (CR) and Curodont Repair Fluoride Plus (Credentis; now manufactured by vVARDIS) on initial caries lesions.