Publications by authors named "Laura Gomez-Hernandez"
The relationship between BDNF and physical activity on depression.
Prog Neuropsychopharmacol Biol Psychiatry
August 2024
Background/objective: Major depressive disorder (MDD) is one of the leading causes of disease burden and disability worldwide. Brain-derived neurotrophic factor (BDNF) seems to have an important role in the molecular mechanisms underlying MDD aetiology, given its implication in regulating neuronal plasticity. There is evidence that physical activity (PA) improves depressive symptoms, with a key role of BDNF in this effect.
View Article and Find Full Text PDFMetabolic and cardiovascular diseases are world-concerning pathologies that affect an important percentage of the population. Nowadays, advances in the genetic background of these diseases allow new approaches to models and therapies, as well as different gene edition trials. Furthermore, technological improvements in gene editing go along with the development of new online and biocomputational tools that provide us alternative ways to explore pathologies.
View Article and Find Full Text PDFArticle Synopsis
- Life starts with a shift in genetic control from the mother to the embryo during a process called zygotic genome activation (ZGA), which is crucial but not fully understood in mammals.
- Researchers found that the orphan nuclear receptor Nr5a2 plays a vital role as an activator of ZGA in mouse embryos, specifically at the two-cell stage.
- Nr5a2 helps regulate a significant portion of ZGA genes, enhancing chromatin accessibility and binding DNA to facilitate gene activation.