Publications by authors named "Laura Gadeyne"
Inflammatory myofibroblastic tumors are rare soft tissue neoplasms with an uncertain biological behavior, derived from fibroblastic and myofibroblastic cells. In rare cases, a peculiar epithelioid phenotypic variant of this tumor is encountered, named epithelioid inflammatory myofibroblastic sarcoma (EIMS). EIMS has overlapping features with inflammatory myofibroblastic tumor but has been correlated with a more aggressive clinical course, a characteristic nuclear membrane or perinuclear anaplastic lymphoma kinase (ALK) immunostaining pattern and a very specific RANBP2-ALK fusion.
View Article and Find Full Text PDFThe emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence of severe immune-related adverse events have prompted the search for predictive biomarkers. A positive predictive value has been attributed to the aberrant expression of Human Leukocyte Antigen-DR (HLA-DR) by melanoma cells, but it remains unknown why this is the case.
View Article and Find Full Text PDFArticle Synopsis
- - Granulomatosis with polyangiitis (GPA) is an inflammatory disease linked to small and medium-sized vessel damage, which presents complexities in diagnosis due to its various symptoms affecting multiple organs.
- - A critical component of diagnosing GPA involves the detection of anti-neutrophil cytoplasmic antibodies (ANCAs) and collaboration with pathologists to avoid misdiagnosis, such as mistaking it for metastatic cancer.
- - In a reported case, a woman initially suspected of having metastatic cancer was correctly diagnosed with GPA through a breast biopsy, leading to successful treatment and full recovery.