Caloric restriction and refeeding promoted different metabolic effects in fat depots and impaired dyslipidemic profile in rats.

Objective: We investigated the effects of severe caloric restriction and refeeding with a high-fat diet on lipid uptake by visceral adipose fat and lipid profile in rats.

Methods: Rats were assigned to six groups: a chow diet (C), a high-fat diet (H), severe caloric restriction (SC and SH), and severe caloric restriction plus refeeding (SC-r and SH-r) during 8 wk. All animals were killed by decapitation 4 h after intragastric administration of [1-14C] triolein ( approximately 0.