An Evolutionary Perspective on Hox Binding Site Preferences in Two Different Tissues.

Transcription factor (TF) networks define the precise development of multicellular organisms. While many studies focused on TFs expressed in specific cell types to elucidate their contribution to cell specification and differentiation, it is less understood how broadly expressed TFs perform their precise functions in the different cellular contexts. To uncover differences that could explain tissue-specific functions of such TFs, we analyzed here genomic chromatin interactions of the broadly expressed Hox TF Ultrabithorax (Ubx) in the mesodermal and neuronal tissues using bioinformatics.