Publications by authors named "Laura Fernandez-Blanco"
Article Synopsis
- Methotrexate (MTX) is a common medicine for rheumatoid arthritis, but it may affect how well people’s immune systems respond to vaccines and infections.
- In a study, researchers looked at how MTX treatment affected immune responses in patients who received a COVID-19 vaccine compared to healthy people and others not on MTX.
- They found that while many immune cells were similar between patients and controls, those on MTX had fewer activated CD4 T cells, leading to slower antibody responses after vaccination.
Optic neuritis, a primary clinical manifestation commonly observed in multiple sclerosis (MS), is a major factor leading to permanent loss of vision. Despite decreased vision (optic neuritis), diplopia, and nystagmus, the immunopathology of the optic nerve in MS is unclear. Here, we have characterized the optic nerve pathology in a large cohort of MS cases (n = 154), focusing on the immune responses in a sub-cohort of MS (n = 30) and control (n = 6) cases.
View Article and Find Full Text PDFCigarette smoke is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on the progressive deterioration of airways has been extensively studied, but its direct effects on the pulmonary vasculature are less known. To prove that pulmonary arterial remodeling in patients with COPD is not just a consequence of alveolar hypoxia but also due to the direct effects of cigarette smoke on the pulmonary vascular bed.
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