Publications by authors named "Laura Eurelings"
Article Synopsis
- This study evaluated how effective adalimumab is for treating noninfectious uveitis and explored why some patients stop using it, including its side effects.
- The analysis included 341 patients from two eye care centers in Rotterdam between 2004 and 2020, focusing on outcomes like achieving inactive disease and reasons for treatment discontinuation.
- Results indicated that adalimumab was effective, with 178 patients reaching inactive disease, and while some experienced relapses, many maintained remission even after stopping the drug, suggesting it has a manageable side effect profile.
Background: The soluble interleukin 2 receptor (sIL-2R) has been proposed as a marker of disease activity in patients with sarcoidosis. However, no studies have evaluated whether serum sIL-2R measurement is of use in establishing the diagnosis of sarcoidosis in patients who are suspected of sarcoidosis among other diseases.
Methods: A cohort study was conducted, consisting of new patients who visited the immunology outpatient clinic and whose serum sIL-2R levels were available before a definitive diagnosis was established between February 2011 and February 2016.
Background/aims: The diagnostic properties of conventional diagnostic tests (ACE and chest radiography) for sarcoidosis-associated uveitis are not ideal. The diagnostic value of lymphopaenia for sarcoidosis-associated uveitis is investigated.
Methods: A retrospective study of 191 consecutive patients with a first uveitis episode visiting the ophthalmology department (Erasmus Medical Center, Rotterdam, The Netherlands).
Relevance of erythrocyte sedimentation rate and C-reactive protein in patients with active uveitis.
Graefes Arch Clin Exp Ophthalmol
January 2019
Purpose: To relate erythrocyte sedimentation rates (ESR) and C-reactive protein (CRP) values to different uveitis entisties.
Methods: A retrospective study of patients with a first episode of active uveitis visiting the Erasmus University Medical Center, uveitis clinic, Rotterdam, the Netherlands, was performed. Levels of ESR and CRP were determined within 2 weeks and 1 week after onset of uveitis, respectively.
Importance: New and improved diagnostic tests for sarcoidosis-associated uveitis are needed because the currently available laboratory diagnostic biomarkers (eg, lysozyme and angiotensin-converting enzyme [ACE]) are lacking in high sensitivity and specificity.
Objective: To compare the value of soluble interleukin 2 receptor (sIL-2R) with ACE as diagnostic biomarkers of sarcoidosis in patients with uveitis.
Design, Setting, And Participants: A cross-sectional retrospective study was conducted using data collected from 249 consecutive patients with uveitis at the Erasmus University Medical Center uveitis outpatient clinic, Rotterdam, the Netherlands, from April 3, 2013, through November 25, 2015.