The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAF.

Background And Purpose: Over past decades, targeted therapies and immunotherapy have improved survival and reduced the morbidity of patients with BRAF-mutated melanoma. However, drug resistance and relapse hinder overall success. Therefore, there is an urgent need for novel compounds with therapeutic efficacy against BRAF-melanoma.

Conservation of Zebrafish MicroRNA-145 and Its Role during Neural Crest Cell Development.

The neural crest is a multipotent cell population that develops from the dorsal neural fold of vertebrate embryos in order to migrate extensively and differentiate into a variety of tissues. A number of gene regulatory networks coordinating neural crest cell specification and differentiation have been extensively studied to date. Although several publications suggest a common role for microRNA-145 (miR-145) in molecular reprogramming for cell cycle regulation and/or cellular differentiation, little is known about its role during in vivo cranial neural crest development.

A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings.

Objective: This study evaluated childhood cognitive functioning in individuals who later developed schizophrenia and in their unaffected siblings.

Method: Through the National Collaborative Perinatal Project, seven subtests of the Wechsler Intelligence Scale for Children were administered at age 7 to 32 individuals who developed schizophrenia in adulthood, 25 of their nonschizophrenic siblings, and 201 demographically similar nonpsychiatric comparison subjects. Mixed model analysis was used to examine between-group differences in standardized scores on the subtests.