biofactory to produce naringenin using a systems biology approach and a bicistronic vector expression strategy in flavonoid production.

Flavonoids are a group of compounds generally produced by plants with proven biological activity, which have recently beeen recommended for the treatment and prevention of diseases and ailments with diverse causes. In this study, naringenin was produced in adequate amounts in yeast after design. The four genes of the involved enzymes from several organisms (bacteria and plants) were multi-expressed in two vectors carrying each two genes linked by a short viral peptide sequence.

Design and Assembly of a Biofactory for (2)-Naringenin Production in : Effects of Oxygen Transfer on Yield and Gene Expression.

The molecule (2)-naringenin is a scaffold molecule with several nutraceutical properties. Currently, (2)-naringenin is obtained through chemical synthesis and plant isolation. However, these methods have several drawbacks.