3D Printing Technologies in Personalized Medicine, Nanomedicines, and Biopharmaceuticals.

3D printing technologies enable medicine customization adapted to patients' needs. There are several 3D printing techniques available, but majority of dosage forms and medical devices are printed using nozzle-based extrusion, laser-writing systems, and powder binder jetting. 3D printing has been demonstrated for a broad range of applications in development and targeting solid, semi-solid, and locally applied or implanted medicines.

Differential Characteristics of Ischemic and Hemorrhagic Stroke in Patients with Cerebral Small Vessel Disease.

Background: Small vessel disease (SVD) is the underlying anatomical substrate for both lacunar infarction and subcortical hemorrhage.

Aim: To assess predictive factors of ischemic or hemorrhagic stroke in patients with cerebral SVD.

Materials And Methods: Prospective hospital-based stroke registry ("The Sagrat Cor Hospital of Barcelona Stroke Registry") in an acute-care teaching hospital in Barcelona, Spain.

Cardioembolic Stroke: Risk Factors, Clinical Features, and Early Outcome in 956 Consecutive Patients.

Background: There is little information about the early clinical features of cardioembolic stroke before complementary examinations.

Objective: The aim of this study was to identify risk factors, clinical features, and early outcomes of cardioembolic stroke.

Methods: Retrospective study based on prospectively collected data available from a university medical center hospitalbased stroke registry.

Eculizumab as a promising treatment in thymoma-associated myasthenia gravis.

Myasthenia gravis is a chronic autoimmune disorder caused by antibodies directed against the neuromuscular junction. Some patients may have an associated thymoma, which confers a worse prognosis. Eculizumab, a monoclonal antibody that inhibits the activation of terminal complement, has recently been approved for the treatment of refractory generalized myasthenia gravis.

Predictive clinical features of cardioembolic infarction in patients aged 85 years and older.

Objective: To assess predictive clinical factors of cardioembolic infarction in very old patients (85 years of age and older).

Methods: Prospective hospital-based stroke registry ("The Sagrat Cor Hospital of Barcelona Stroke Registry") is an acute-care teaching hospital in Barcelona, Catalonia, Spain. From 956 first-ever cardioembolic stroke patients included in the stroke registry over a 24-year period, 639 were younger than 85 years of age and 317 were 85 years or older (mean age: 88.

Versatile Three-Dimensional-Printed Platform for Nitrite Ion Analyses Using a Smartphone with Real-Time Location.

Nitrogen-based chemicals represent one of the most important family of compounds in freshwater and marine ecosystems. The nitrogen cycle is responsible for spreading nitrogen compounds all over the environment in an equilibrium manner. Mankind's industrial activities have harshly contributed to the disruption of the nitrogen cycle and its consequences have severely affected Earth's ecosystems.

Prevalence of cardiovascular risk factors in people with epilepsy.

Objectives: Epilepsy has been associated with cardiovascular comorbidity. This study aimed to assess the potential association between cardiovascular risk factors (CRFs), antiepileptic drugs (AEDs), and etiology.

Material And Methods: A single-center retrospective epilepsy cohort from the decade of 2004-2013 was assessed.

Temporary management of diplopia with botulinum toxin in multiple ocular motor cranial neuropathies.

Purpose: To report management of diplopia with botulinum toxin injection in traumatic multiple ocular motor cranial neuropathies. 


Methods: Alternate prism and cover measurement of deviation in different positions of gaze, examination of ductions, field of binocular single vision, and complete ocular anterior and posterior segment evaluation were carried out. CT and MRI of the orbit were available.

Effect of diinosine polyphosphates on intraocular pressure in normotensive rabbits.

The ability of diinosine polyphosphates, diinosine triphosphate (Ip(3)I), diinosine tetraphosphate (Ip(4)I) and diinosine pentaphosphate (Ip(5)I) to modify intraocular pressure in normotensive New Zealand white rabbits was tested. Ip(5)I produced increase in intraocular pressure, while Ip(3)I and Ip(4)I produced a decrease. Ip(4)I was the most effective reducing intraocular pressure inducing a maximal decrease of intraocular pressure to 74.

[Primary manifestation of Hodgkin lymphoma in adenoid. About a case].

Lymphomas are the second leading cause of malignancy in head and neck. Hodgkin's disease (HD) accounts for only 10-35% of all cases, where the lymph node is affected in 70-80%. We present the case of a patient with HD with extranodal involvement, given the rarity of this entity.