Recent advances in local and systemic nitrate signaling in Arabidopsisthaliana.

Nitrate is the most abundant form of inorganic nitrogen in aerobic soils, serving both as a nutrient and a signaling molecule. Central to nitrate signaling in higher plants is the intricate balance between local and systemic signaling and response pathways. The interplay between local and systemic responses allows plants to regulate their global gene expression, metabolism, physiology, growth, and development under fluctuating nitrate availability.

Effectiveness of repeated injections of botulinum toxin A on gait and fatigue in adults with spastic paraparesis secondary to multiple sclerosis.

Background: Multiple sclerosis (MS) is the most common neurologic disease in young adults. Spasticity is one of its most disabling symptoms, with botulinum toxin A type A (BoNT-A) being one of the treatments of choice for this symptom.

Objective: We assessed the response to abobotulinumtoxinA in improving walking ability and fatigue in patients with spastic paraparesis caused by MS.

AL Amyloidosis and Multiple Myeloma: A Complex Scenario in Which Cardiac Involvement Remains the Key Prognostic Factor.

Monoclonal gammopathies (MGs) are a wide range of diseases that may evolve or progress over time. Comorbidity plays a critical role in this setting. The co-occurrence of two MGs is not a rare event.

Assessing falls in the elderly population using G-STRIDE foot-mounted inertial sensor.

Falls are one of the main concerns in the elderly population due to their high prevalence and associated consequences. Guidelines for the management of the elder with falls are comprised of multidimensional assessments, especially gait and balance. Daily clinical practice needs for timely, effortless, and precise tools to assess gait.

Shining the Light on Astrocytic Ensembles.

While neurons have traditionally been considered the primary players in information processing, the role of astrocytes in this mechanism has largely been overlooked due to experimental constraints. In this review, we propose that astrocytic ensembles are active working groups that contribute significantly to animal conduct and suggest that studying the maps of these ensembles in conjunction with neurons is crucial for a more comprehensive understanding of behavior. We also discuss available methods for studying astrocytes and argue that these ensembles, complementarily with neurons, code and integrate complex behaviors, potentially specializing in concrete functions.

Identifying the origin of acrylamide in Peruvian panela production to inform strategies for its reduction.

Maximum levels of acrylamide have been set by the European Commission (EU) 2017/2158 for several food products due to its carcinogenic properties. Although not regulated yet, European buyers are requesting maximum levels of 0.8 mg kg in artisanal panela (raw cane sugar) from northern Peru.

Ca-modulated photoactivatable imaging reveals neuron-astrocyte glutamatergic circuitries within the nucleus accumbens.

Astrocytes are key elements of brain circuits that are involved in different aspects of the neuronal physiology relevant to brain functions. Although much effort is being made to understand how the biology of astrocytes affects brain circuits, astrocytic network heterogeneity and plasticity is still poorly defined. Here, we have combined structural and functional imaging of astrocyte activity recorded in mice using the Ca-modulated photoactivatable ratiometric integrator and specific optostimulation of glutamatergic pathways to map the functional neuron-astrocyte circuitries in the nucleus accumbens (NAc).

An Attempt to Optimize Supercritical CO Polyaniline-Polycaprolactone Foaming Processes to Produce Tissue Engineering Scaffolds.

Conjugated polymers are biomaterials with high conductivity characteristics because of their molecular composition. However, they are too rigid and brittle for medical applications and therefore need to be combined with non-conductive polymers to overcome or lessen these drawbacks. This work has, consequently, focused on the development of three-dimensional scaffolds where conductive and non-conductive polymers have been produced by combining polycaprolactone (PCL) and polyaniline (PANI) by means of supercritical CO foaming techniques.

Immunosuppressive Treatment With mTOR Inhibitors for Malignancies After Liver Transplantation: Long-Term Survival Retrospective Analysis.

Background: Immunosuppressive calcineurin inhibitors have been associated with an increased risk of post-transplant malignancies. The mammalian target of rapamycin inhibitors (mTORi) is an alternative immunosuppressive regimen with an antineoplastic effect. The aim of the study was to determine the long-term survival of mTORi-treated recipients with de novo or recurring tumors after liver transplantation (LT).

Hemophagocytic Syndrome as Uncommon Cause of Severe Pancytopenia After Liver Transplantation.

A rare but life-threatening cause of pancytopenia after liver transplantation is hemophagocytic syndrome. We present a 48-year-old woman who underwent liver transplantation and developed a hemophagocytic syndrome secondary to Epstein-Barr virus with a fatal course, despite initial treatment with immunosuppressants. The diagnosis was made based on the bone marrow aspiration, in which macrophages with phagocytic activity were observed, and clinical findings.

Application of a JA-Ile Biosynthesis Inhibitor to Methyl Jasmonate-Treated Strawberry Fruit Induces Upregulation of Specific MBW Complex-Related Genes and Accumulation of Proanthocyanidins.

Fleshy fruits are an important source of anthocyanins and proanthocyanidins (PAs), which protect plants against stress, and their consumption provides beneficial effects for human health. In strawberry fruit, the application of exogenous methyl jasmonate (MeJA) upregulates anthocyanin accumulation, although the relationship between the jasmonate pathway and anthocyanin and PA biosynthesis in fruits remains to be understood. Anthocyanin and PA accumulation is mainly regulated at the transcriptional level through R2R3-MYB and bHLH transcription factors in different plant species and organs.

[Pediatric acute liver failure. Working group of the Latinamerican Society of Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN).].

Pediatric acute liver failure is a syndrome ofsevere and sudden dysfunction of the hepatocytes which produces a failure in synthetic and detoxifyingfunction. It is an infrequent and severe disease butpotentiallyfatal, occurring in children with no prior history of liver disease. Etiology is related to the age and geographic region of the patient, recognizing the origin: metabolic, infectious, drug exposure, autoinmune, vascular and oncologic.

Anti-proliferative effects of quercetin and catechin metabolites.

Dietary flavonoids have been associated with a lower incidence of some chronic diseases. However, the mechanisms behind the in vivo biological activity of flavonoids are still mostly unknown. Flavonoids are metabolized in the human body to conjugated forms (methylated, sulphated and glucuronidated derivatives) that should play a role in flavonoid activity.

Oxidative status of stressed Caenorhabditis elegans treated with epicatechin.

The aim of this work was to examine the mechanisms involved in the in vivo antioxidant effects of epicatechin (EC), a major flavonoid in the human diet. The influence of EC in different oxidative biomarkers (reactive oxygen species (ROS) production, intracellular glutathione, activity of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD)) was studied in the model organism Caenorhabditis elegans . Under thermal stress condition, exposure of the worms (wild type N2 strains) to EC (200 μM) significantly reduced ROS levels (up to 28%) and enhanced the production of reduced glutathione (GSH).

[Larval seasonality of the mosquito Anopheles aquasalis (Diptera: Culicidae) and other insects associated to its habitat in Sucre, Venezuela].

Anopheles aquasalis Curry is considered the main vector of human malaria in Northern Venezuela. A longitudinal study was carried out in the coastal areas of the Paria Peninsula, Sucre state. The larval habitats of A.

Impact of imported malaria on the burden of disease in northeastern Venezuela.

Background: Many countries throughout the world are reporting an increasing number of imported malaria cases. It is now well documented that population movements play an important role in the spread and introduction of malaria infection in nonendemic areas.

Methods: We evaluated the contribution of imported malaria to the overall malaria burden of disease in an already endemic malaria region in Venezuela, where malaria is exclusively caused by Plasmodium vivax.

Association of cyclopoid copepods with the habitat of the malaria vector Anopheles aquasalis in the peninsula of Paria, Venezuela.

The southern region of the Paria Peninsula shows a high malaria incidence. This work relates the abundances of cyclopoid species and the malaria vector Anopheles aquasalis to certain abiotic parameters and vegetation features. Samples were collected over a 4-month period in several habitats, including marsh, irrigation channel, lagoon, and mangrove swamp during the wet season and the wet-dry transition.