Publications by authors named "Laura Cristina Cabrera Perez"
Article Synopsis
- Valproic acid (VPA) is associated with liver damage, but a new compound derived from it, HO-AAVPA, shows improved antiproliferative effects against cancer.
- A study on HO-AAVPA involved testing its effects on liver toxicity in rats and mice, with results indicating it has a higher median lethal dose (LD) than 2000 mg/kg and does not cause liver injury at therapeutic doses.
- Compared to VPA, HO-AAVPA led to fewer liver lesions and less disruption to liver enzyme levels, suggesting it could be a safer alternative for cancer treatment without the risk of hepatotoxicity.
Design, Synthesis and Biological Evaluation of a Phenyl Butyric Acid Derivative, N-(4-chlorophenyl)-4-phenylbutanamide: A HDAC6 Inhibitor with Anti-proliferative Activity on Cervix Cancer and Leukemia Cells.
Rolando Alberto Rodríguez-Fonseca Yudibeth Sixto-López M Jonathan Fragoso-Vázquez Raul Flores-Mejía Laura Cristina Cabrera-Pérez
Anticancer Agents Med Chem
October 2017
Background: The epigenetic regulation of genes in cancer could be targeted by inhibiting Histone deacetylase 6 (HDAC6), an enzyme involved in several types of cancer such as lymphoma, leukemia, ovarian cancer, etc.
Objective: Through in silico methods, a set of Phenyl butyric acid derivatives with possible HDAC6 inhibitory activity were designed, rendering monophenylamides and biphenylamides using tubacin (HDAC6 selective inhibitor) as reference.
Method: The target compounds were submitted to theoretical ADMET analyses and their binding properties on different HDAC6 conformers were evaluated through docking calculations.