Stimulus conditions that promote habitual control.

Two experiments in rats examined how training where a stimulus signaled when to respond for reward, conditions that should favour S-R learning, might lead to habitual control of behaviour. Experiment 1 investigated how animals trained with a stimulus preceding lever insertion would impact learning relative to a group that was self-paced and could control lever insertion with a second, distinct response. Rats were then tested for sensitivity to outcome devaluation to distinguish between goal-directed and habitual control.

Outcome devaluation as a method for identifying goal-directed behaviors in rats.

Goal-directed behaviors allow animals to act to satisfy needs and desires. The outcome devaluation task is an effective method for identifying goal-directed behaviors and distinguishing these from other types of behavior. Rats can be trained to lever-press for one or multiple distinct food rewards.

Cue-potentiated feeding in rodents: Implications for weight regulation in obesogenic environments.

Cue-potentiated feeding (CPF) describes instances where food intake is increased by exposure to conditioned cues associated with food, often in the absence of hunger. CPF effects have been reported in a range of experimental protocols developed by researchers working across diverse fields spanning behavioural neuroscience, social psychology and ecology. Here we review the evolution of research on cue-potentiated feeding in animal models to identify important behavioural parameters and key neural circuits and pharmacological systems underlying the effect.

Manipulations of the context-response relationship reduce the expression of response habits.

Habitual instrumental behaviour is believed to rely on stimulus-response (S-R) associations. However, the method most commonly used to identify habitual behaviour, outcome devaluation, provides only indirect evidence of S-R control. Therefore, it is important to have a better understanding of the S-R association believed to underlie habitual responding.

Ceftriaxone reverses diet-induced deficits in goal-directed control.

Rationale: Obesity is associated with numerous health risks and ever-increasing rates are a significant global concern. However, despite weight loss attempts many people have difficulty maintaining weight loss. Previous studies in animals have shown that chronic access to an obesogenic diet can disrupt goal-directed behavior, impairing the ability of animals to flexibly adjust food-seeking behavior following changes in the value of earned outcomes.

Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats.

Extinction is a specific example of learning where a previously reinforced stimulus or response is no longer reinforced, and the previously learned behaviour is no longer necessary and must be modified. Current theories suggest extinction is not the erasure of the original learning but involves new learning that acts to suppress the original behaviour. Evidence for this can be found when the original behaviour recovers following the passage of time (spontaneous recovery) or reintroduction of the reinforcement (i.

Ghrelin receptor antagonism and satiety attenuate Pavlovian-instrumental transfer.

Animals rely on learned cues to guide their behaviour for rewards such as food. The Pavlovian-instrumental transfer (PIT) task can be used to investigate the influence of Pavlovian stimuli on instrumental responding. Ghrelin, an orexigenic peptide, and its receptor, growth hormone secretagogue receptor 1A (GHS-R1A), has received growing interest for its role in reward-motivated learning and behaviours.

Serotonin and Dopamine Show Different Response Profiles to Acute Stress in the Nucleus Accumbens and Medial Prefrontal Cortex of Rats with Neuropathic Pain.

The ability to adaptively guide behaviour requires the integration of external information with internal motivational factors. Decision-making capabilities can be impaired by acute stress and is often exacerbated by chronic pain. Chronic neuropathic pain patients often present with cognitive dysfunction, including impaired decision-making.

Food for thought: diet-induced impairments to decision-making and amelioration by N-acetylcysteine in male rats.

Rationale: Attempts to lose weight often fail despite knowledge of the health risks associated with obesity and determined efforts. We previously showed that rodents fed an obesogenic diet displayed premature habitual behavioural control and weakened flexible decision-making based on the current value of outcomes produced by their behaviour. Thus, habitual control may contribute to failed attempts to modify eating behaviours.

The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour.

Rationale: Adenosine A receptors (AR) in the dorsal striatum have been implicated in goal-directed behaviour. While activation of these receptors with several methods has resulted in an insensitivity to outcome devaluation, particular explanations for how they disrupt behaviour have not been explored. We both confirm a role for A receptors in goal-directed responding and evaluate additional behavioural aspects of goal-directed control to more fully understand the role of A receptors in instrumental behaviour.

Diet-induced deficits in goal-directed control are rescued by agonism of group II metabotropic glutamate receptors in the dorsomedial striatum.

Many overweight or obese people struggle to sustain the behavioural changes necessary to achieve and maintain weight loss. In rodents, obesogenic diet can disrupt goal-directed control of responding for food reinforcers, which may indicate that diet can disrupt brain regions associated with behavioural control. We investigated a potential glutamatergic mechanism to return goal-directed control to rats who had been given an obesogenic diet prior to operant training.

Engram Size Varies with Learning and Reflects Memory Content and Precision.

Memories are rarely acquired under ideal conditions, rendering them vulnerable to profound omissions, errors, and ambiguities. Consistent with this, recent work using context fear conditioning has shown that memories formed after inadequate learning time display a variety of maladaptive properties, including overgeneralization to similar contexts. However, the neuronal basis of such poor learning and memory imprecision remains unknown.

Problematic eating as an issue of habitual control.

Obesity has reached alarming rates worldwide. Although many people attempt to control weight by modifying their food-related behaviours, this typically only has short-term effects and most dieters regain the weight that was lost. Why do so many people struggle to regulate their food-related behaviours? One possible explanation is that these behaviours have become habits that are not immediately sensitive to their consequences.

Neural substrates of appetitive and aversive prediction error.

Prediction error, defined by the discrepancy between real and expected outcomes, lies at the core of associative learning. Behavioural investigations have provided evidence that prediction error up- and down-regulates associative relationships, and allocates attention to stimuli to enable learning. These behavioural advances have recently been followed by investigations into the neurobiological substrates of prediction error.

Relating goal-directed behaviour to grazing in persons with obesity with and without eating disorder features.

Background: Both obesity and eating disorders (ED) have been associated with reductions in purposeful, flexible goal-directed behaviour, and with an overreliance on more rigid habitual behaviour. It is currently unknown whether grazing, an eating style which is common in both conditions, is related to goal-directed behaviour. The current study therefore aimed to relate grazing to goal-directed behaviour in a group of participants with obesity with and without ED features, compared to a healthy-weight control group.

The role of the response-outcome association in the nature of inhibitory Pavlovian-instrumental transfer in rats.

Inhibitory stimuli can reduce animals' reward seeking in an outcome-specific manner or outcome-general manner. However, we do not understand the factors that determine which of these effects are produced. To address this, we carried out three experiments which examined whether instrumental training with one or multiple outcomes determined the nature of subsequently observed Pavlovian-instrumental transfer (PIT).

Maladaptive Properties of Context-Impoverished Memories.

The context in which sudden fearful events occur can be poorly encoded into memory. Yet, the consequences of the resulting context-impoverished memories remain unknown. We demonstrate that restricting the time available for context encoding during contextual fear conditioning causes maladaptively overgeneralized and inextinguishable fear.

Altered monoamine levels in the dorsal striatum of the rat are associated with alterations in behavioural selection and motivation following peripheral nerve injury and acute stress.

Chronic neuropathic pain and psychological stress interact to compromise goal-directed control over behaviour following mild psychological stress. The dorsomedial (DMS) and dorsolateral (DLS) striatum in the rat are crucial for the expression of goal-directed and habitual behaviours, respectively. This study investigated whether changes in monoamine levels in the DMS and DLS following nerve injury and psychological stress reflect these behavioural differences.

The role of serotonin 1B in the representation of outcomes.

Disrupted serotonin neurotransmission has been implicated in the etiology of psychopathic traits. Empirical research has found that people with high levels of psychopathic traits have a deficit in reinforcement learning that is thought to be linked with amygdala dysfunction. Altered serotonin neurotransmission provides a plausible explanation for amygdala dysfunction in psychopathic traits and recent research suggests that this may be associated with serotonin 1B (5-HT) receptor function.

Noradrenergic β-receptor antagonism in the basolateral amygdala impairs reconsolidation, but not extinction, of alcohol self-administration: Intra-BLA propranolol impairs reconsolidation of alcohol self-administration.

A critical barrier to recovery from alcohol addiction is relapse propensity. Alcohol cues can trigger relapse, and pharmacologically facilitating processes such as extinction, which decreases cue associations, may help prevent relapse. The noradrenergic system mediates extinction learning for alcohol; however, the neural locus of this effect is unknown.

Variety overcomes the specificity of cue-potentiated feeding in rats.

Cue-potentiated feeding (CPF) describes the stimulation of food consumption by cues that have become associated with food. Determining under what Conditions CPF occurs is important to better understand how exposure to food cues contributes to overeating. CPF is typically found to be specific: cues enhance consumption only of the food they have signaled.

Grazing in adults with obesity and eating disorders: A systematic review of associated clinical features and meta-analysis of prevalence.

Grazing, the unstructured, repetitive eating of small amounts of food, is a pattern of eating which has been associated with negative outcomes following bariatric surgery. Less is known about grazing in eating disorders and in non-surgical obese samples. This review aims to critically examine the existing research on the prevalence of grazing, associated treatment outcomes, and clinical correlates in adults with eating disorders and/or obesity, in clinical and community settings.

Methamphetamine promotes habitual action and alters the density of striatal glutamate receptor and vesicular proteins in dorsal striatum.

Goal-directed actions are controlled by the value of the consequences they produce and so increase when what they produce is valuable and decrease when it is not. With continued invariant practice, however, goal-directed actions can become habits, controlled not by their consequences but by antecedent, reward-related states and stimuli. Here, we show that pre-exposure to methamphetamine (METH) caused abnormally rapid development of habitual control.