Publications by authors named "Laura Compton"
Article Synopsis
- This study investigated the relationship between plasma neurofilament light chain (pNfL) levels and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
- It compared pNfL concentrations in various groups: treatment-naïve patients before and after IVIg treatment, those on IVIg with stable vs. unstable disease, and patients whose IVIg was suspended to monitor disease activity.
- Results showed that higher pNfL levels are associated with unstable CIDP and may indicate active disease, suggesting pNfL could serve as a valuable biomarker for assessing disease status.
Article Synopsis
- * A study compared the effects of stopping immunoglobulin treatment versus gradually reducing the dose in 33 stable CIDP patients, finding that many were dependent on the treatment.
- * Results showed a significant clinical decline in function after treatment cessation, but patients were able to return to their baseline status relatively quickly after restarting treatment; some even remained stable without treatment for over 2 years.
Article Synopsis
- The study focuses on switching patients with inflammatory neuropathies from intravenous immunoglobulin (IVIg) to subcutaneous immunoglobulin (SCIg), assessing the effectiveness of dosing strategies.* -
- A total of 44 out of 56 patients maintained their SCIg treatment for an average of 3.3 years with stable clinical outcomes; however, some needed dose adjustments over time for better management.* -
- The findings suggest that adjusting doses based on patient response is a viable method for maintaining effective SCIg therapy, although some patients reverted back to IVIg due to relapses or personal choice.*
Background: Antidepressant-induced excessive sweating (ADIES) is a side effect that occurs in approximately 22% of patients taking antidepressant medications and can negatively affect patient medication adherence.
Local Problem: Primary care providers may not have adequate knowledge of ADIES management. The aims of this project were to increase primary care provider's overall perceived knowledge related to ADIES, improve confidence in the management of ADIES, and gather input on the perceived usefulness of the initial clinical practice guideline (CPG) for ADIES management.
Inverse bicontinuous cubic structures formed by lipids have been demonstrated in a wide variety of applications, from a host matrix for proteins for crystallisation, to templates for nanoscale structures. Recent work has focused on tuning their properties to realize such applications, often by manipulating the structure by introducing other lipids with different properties such as charge or packing. However, they are often prepared in the presence of solutions containing salt, counteracting the effects, for example, charged lipids, and fundamentally changing the structures obtained.
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