Publications by authors named "Laura Cardenas"

Objective: To assess the safety of fertility-sparing treatments for early-stage ovarian cancer in women younger than 40 years old.

Methods: We performed a retrospective multicenter study including women aged 18-40 years diagnosed with early-stage (FIGO I-II) ovarian cancer in 55 Spanish hospitals, from January 2010 to December 2019. Benign and borderline tumors were excluded, as well as advanced stages (FIGO III-IV).

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Objective: Management of endometrial cancer is advancing, with accurate staging crucial for guiding treatment decisions. Understanding sentinel lymph node (SLN) involvement rates across molecular subgroups is essential. To evaluate SLN involvement in early-stage (International Federation of Gynecology and Obstetrics 2009 I-II) endometrial cancer, considering molecular subtypes and new European Society of Gynaecological Oncology (ESGO) risk classification.

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This study addresses the effect of using animal excreta on the nutritional content of forages, focusing on macro- and micro-element concentrations (nitrogen; N, phosphorus; P, sulphur; S, copper; Cu, zinc; Zn, manganese; Mn, selenium; Se) from animal feed to excreta, soil, and plants. Data were collected from pot and field trials using separate applications of sheep or cattle urine and faeces. Key findings indicate that soil organic carbon (SOC) and the type of excreta significantly influences nutrient uptake by forages, with varied responses among the seven elements defined above.

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Agricultural soils are a major source of the potent greenhouse gas and ozone depleting substance, NO. To implement management practices that minimize microbial NO production and maximize its consumption (i.e.

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Grazing livestock plays an important role in the context of food security, agricultural sustainability and climate change. Understanding how livestock move and interact with their environment may offer new insights on how grazing practices impact soil and ecosystem functions at spatial and temporal scales where knowledge is currently limited. We characterized daily and seasonal grazing patterns using Global Positioning System (GPS) data from two grazing strategies: conventionally- and rotationally-grazed pastures.

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Purpose: To validate Pediatric Refractive Error Profile 2 (PREP2) subscales that can be used to evaluate contact lens wearers and compare vision-specific quality of life measurements between children wearing multifocal and single vision contact lenses for 2 weeks.

Methods: Two hundred and ninety-four myopic children aged 7-11 years (inclusive) were enrolled in the 3-year, double-masked Bifocal Lenses In Nearsighted Kids (BLINK) Study. Participants completed the PREP2 survey after having worn contact lenses for 2 weeks.

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Achieving food security requires resilient agricultural systems with improved nutrient-use efficiency, optimized water and nutrient storage in soils, and reduced gaseous emissions. Success relies on understanding coupled nitrogen and carbon metabolism in soils, their associated influences on soil structure and the processes controlling nitrogen transformations at scales relevant to microbial activity. Here we show that the influence of organic matter on arable soil nitrogen transformations can be decoded by integrating metagenomic data with soil structural parameters.

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Article Synopsis
  • Women with Lynch syndrome (LS) have a higher risk of endometrial cancer (EC) due to issues like mismatch repair (MMR) deficiencies and microsatellite instability (MSI), prompting investigation into effective gynecologic surgery timing.
  • A study involving 93 LS women, 25 sporadic EC patients, and 30 benign disease controls assessed highly sensitive MSI (hs-MSI) in endometrial aspirates, revealing that hs-MSI was positively correlated with MMR-deficient cancer cases and loss of certain protein expressions.
  • The findings suggest that hs-MSI scores can help identify both premalignant and malignant conditions in LS carriers, potentially improving individualized surveillance strategies and surgical decision-making.
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Healthy soils are key to sustainability and food security. In temperate grasslands, not many studies have focused on soil health comparisons between contrasting pasture systems under different management strategies and treatment applications (e.g.

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Article Synopsis
  • Scientists studied how nitrogen (N) moves from white clover plants to ryegrass plants in a shared field to see if clover could help ryegrass get enough nitrogen.
  • They found that only a little nitrogen actually transferred to the ryegrass, mostly from the clover's roots releasing it and from decomposing plant parts.
  • The amount of nitrogen that did transfer was affected by things like soil bugs, which can help or hurt the process, and how the land was managed, like whether animals grazed there.
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The inclusion of plant extracts that contain secondary compounds with the potential to modulate rumen fermentation and improve animal performance has gained attention in recent years. The aim of this study was to evaluate the effect of the inclusion of yerba mate extract (Ilex paraguariensis ST. Hilaire) (YME) on the ruminal parameters.

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According to the available guidelines, good practices for calculating nitrous oxide (NO) emission factors (EFs) for livestock excreta and manure application include that sampling duration should be of at least one year after the nitrogen (N) application or deposition. However, the available experimental data suggest that in many cases most emissions are concentrated in the first months following N application. Therefore resources could be better deployed by measuring more intensively during a shorter period.

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Article Synopsis
  • Screenwide is a case-control study conducted in Spain from 2017 to 2021 that looked at women with endometrial and ovarian cancers, along with BRCA1/2 and MMR pathogenic variant carriers, to identify risk factors and molecular biomarkers for these cancers.
  • Participants provided detailed personal and medical information, along with biological samples like blood and self-collected vaginal specimens, to facilitate comprehensive analyses.
  • Preliminary findings from a pilot study indicate that certain genetic variants associated with tumors can be effectively detected in less invasive samples, suggesting potential for improved early detection strategies for gynecological cancers.
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Percutaneous biopsies (PBs) are the gold standard diagnostic procedures indicated for renal and hepatic disorders. Nevertheless, they can cause hemorrhages and are contraindicated for coagulopathic patients. In this study we designed, fabricated, and evaluated a small intestinal submucosa (SIS) plug to reduce, and potentially cease, bleeding to decrease death risk after percutaneous hepatic and renal biopsies in healthy and coagulopathic in vivo models.

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Negative pressure wound therapy (NPWT) is widely used in skin defects, active infection, and surgical reconstruction; lately, it is being used after skin graft to improve the adhesion on the receptor area. During the last decade, another indication has been identified: the use of NPTW to avoid complications after free flaps such as venous congestion and the risk of necrosis. NPWT can be used in the initial complication of a free flap, and the venous congestions can be treated with this technique, with very good outcomes.

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In a field experiment, annual nitrous oxide (NO) emissions and grassland yield were measured across different plant communities, comprising systematically varying combinations of monocultures and mixtures of three functional groups (FG): grasses (Lolium perenne, Phleum pratense), legumes (Trifolium pratense, Trifolium repens) and herbs (Cichorium intybus, Plantago lanceolata). Plots received 150 kg ha year nitrogen (N) (150 N), except L. perenne monocultures which received two N levels: 150 N and 300 N.

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In grazing systems, urine patches deposited by livestock are hotspots of nutrient cycling and the most important source of nitrous oxide (NO) emissions. Studies of the effects of urine deposition, including, for example, the determination of country-specific NO emission factors, require natural urine for use in experiments and face challenges obtaining urine of the same composition, but of differing concentrations. Yet, few studies have explored the importance of storage conditions and processing of ruminant urine for use in subsequent gaseous emission experiments.

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Understanding the behaviour of grazing animals at pasture is crucial in order to develop management strategies that will increase the potential productivity of grazing systems and simultaneously decrease the negative impact on the environment. The objective of this review was to summarize and analyse the scientific literature that has addressed the site use preference of grazing cattle using global positioning systems (GPS) collars in the past 21 years (2000-2020) to aid the development of more sustainable grazing livestock systems. The 84 studies identified were undertaken in several regions of the world, in diverse production systems, under different climate conditions and with varied methodologies and animal types.

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The prevalence of Chagas disease has decreased in the Americas region due to vector control measures. However, non-vectorial transmission through blood transfusions and organ transplantation has gained importance in recent years. Screening among blood and organ donors are essential to reduce transmission and could provide information to estimate population prevalence.

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Adequately estimating soil nitrous oxide (N O) emissions using static chambers is challenging due to the high spatial variability and episodic nature of these fluxes. We discuss how to design experiments using static chambers to better account for this variability and reduce the uncertainty of N O emission estimates. This paper is part of a series, each discussing different facets of N O chamber methodology.

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The application of organic materials to soil can recycle nutrients and increase organic matter in agricultural lands. Digestate can be used as a nutrient source for crop production but it has also been shown to stimulate greenhouse gas (GHG) emissions from amended soils. While edaphic factors, such as soil texture and pH, have been shown to be strong determinants of soil GHG fluxes, the impact of the legacy of previous management practices is less well understood.

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Nitrous oxide (N O) is an air pollutant of major environmental concern, with agriculture representing 60% of anthropogenic global N O emissions. Much of the N O emissions from livestock production systems result from transformation of N deposited to soil within animal excreta. There exists a substantial body of literature on urine patch N O dynamics, we aimed to identify key controlling factors influencing N O emissions and to aid understanding of knowledge gaps to improve GHG reporting and prioritize future research.

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