Publications by authors named "Laura Canullo"
Article Synopsis
- The study analyzed how many patients with coronary heart disease (CHD) in Italy are meeting the recommended LDL-cholesterol levels: less than 70 mg/dl for guidelines and 100 mg/dl for reimbursement eligibility.
- Among 676 CHD patients, 93.3% on lipid-lowering therapy had lower LDL-C levels, but only 35.4% actually reached the target.
- The findings indicate that increasing the statin dose is crucial for target attainment, and adding ezetimibe could significantly improve lipid levels while reducing the need for more expensive treatments.
The synthesis and biological evaluation of a series of new derivatives of 2-substituted 5-phenyl-1,4-benzodiazepines, structurally related to tifluadom (5), are reported. Chemical and pharmacological studies on compounds 6 have been pursued with the aim of expanding the SAR data and validating the previously proposed model of interaction of this class of compounds with the kappa-opioid receptor. The synthesis of the previously described compounds 6 has been reinvestigated in order to obtain a more direct synthetic procedure.
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