Publications by authors named "Laura Caffi"
Conventional DBS (cDBS) for Parkinson's disease uses constant, predefined stimulation parameters, while the currently available adaptive DBS (aDBS) provides the possibility of adjusting current amplitude with respect to subthalamic activity in the beta band (13-30 Hz). This preliminary study on one patient aims to describe how these two stimulation modes affect basal ganglia dynamics and, thus, behavior in the long term. We collected clinical data (UPDRS-III and -IV) and subthalamic recordings of one patient with Parkinson's disease treated for one year with aDBS, alternated with short intervals of cDBS.
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- Gait disturbances significantly impact the quality of life for Parkinson's disease patients, with current treatments only providing limited benefits.
- Deep brain stimulation (DBS) usually targets symptoms like tremors, but is not very effective for improving gait issues.
- A novel approach called adaptive DBS was tested on one patient, leading to notable improvements in walking and overall symptom management, suggesting it may help optimize stimulation for better gait outcomes.