Background: The higher number of cases and deaths caused by COVID-19 in Colombia occurred during the third epidemic peak, where the Mu variant was associated with 50% of the cases.
Objective: To evaluate the association between the clinical outcome of COVID-19 with health conditions and SARS-CoV-2 lineages.
Methods: In this study, clinical metadata and SARS-CoV-2 lineages from 535 patients with different degrees of COVID-19 severity were obtained after the SARS-CoV-2 genomic surveillance in Colombia.