Publications by authors named "Laura Brugnara"

Article Synopsis
  • Myosteatosis refers to the abnormal buildup of fat in skeletal muscle, which is associated with various health risks, including aging, chronic diseases, and lower muscle quality, but is distinct from sarcopenia.
  • It negatively impacts muscle function by causing inflammation and compromising mitochondrial efficiency, which can lead to decreased strength and mobility.
  • Current imaging techniques like CT, MRI, and ultrasound are used to assess myosteatosis, but there is no standardized definition or consensus on assessment methods in clinical practice.
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Aims: We aimed to assess physical activity (PA) levels, adherence to PA guidelines, and fitness capacity in individuals with type 1 diabetes (T1D) and control population.

Methods: This cross-sectional study included 232 T1D and 248 controls. PA levels (IPAQ-SF questionnaire), adherence to guidelines (>150 min/week of moderate-to-vigorous PA), fitness capacity (VOmax, maximal incremental test on a cycle ergometer and 1RM test) were assessed, along with other clinical variables.

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Introduction: Physical activity (PA) is highly recommended in type 1 diabetes (T1D). Few studies have reported the amount of PA performed by individuals with T1D in their daily life, and there is no information about changes over time.

Material And Methods: Cross-sectional study in patients with T1D from a referral hospital recruited in two different periods: data from the Biobank registers from 2009 and data from patients attending visits at the hospital in 2019, on a consecutive basis.

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Aims: to investigate if a High Intensity Interval Training (HIIT) protocol improves glycemic control and fitness capacity, compared to traditional moderate Intensity Continuous Training (MICT) exercise.

Methods: 30 sedentary individuals with type 1 diabetes (T1D) and 26 healthy controls were assigned to a 3-week HIIT or MICT protocol. Blood glucose levels by continuous glucose monitoring system and fitness status were compared before and after the study period.

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Liver fibrosis staging is a key element driving the prognosis of patients with chronic liver disease. Currently, biopsy is the only technique capable of diagnosing liver fibrosis in patients with alcohol-related liver disease (ArLD) and nonalcoholic fatty liver disease (NAFLD) unequivocally. Noninvasive (e.

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Purpose: Muscle is an essential organ for glucose metabolism and can be influenced by metabolic disorders and physical activity. Elevated muscle carnosine levels have been associated with insulin resistance and cardiometabolic risk factors. Little is known about muscle carnosine in type 1 diabetes (T1D) and how it is influenced by physical activity.

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Objective: To investigate physiological responses to cardiopulmonary exercise (CPX) testing in adults with type 1 diabetes compared with age-, sex-, and BMI-matched control participants without type 1 diabetes.

Research Design And Methods: We compared results from CPX tests on a cycle ergometer in individuals with type 1 diabetes and control participants without type 1 diabetes. Parameters were peak and threshold variables of VO, heart rate, and power output.

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Article Synopsis
  • The study aimed to compare the effectiveness of diffusion-weighted imaging (DWI), dynamic contrast-enhanced MRI (DCE-MRI), and F-FDG PET/CT in diagnosing diabetic foot osteomyelitis (DFO) versus Charcot neuro-osteoarthropathy (CN).
  • Thirty-one diabetic patients were analyzed using various imaging parameters, and diagnostic accuracy was assessed through statistical methods like the area under the receiver operating characteristic curve (AUC).
  • Results showed that DWI and DCE-MRI were reliable for differentiating between DFO and CN, especially with larger regions of interest, but visual assessment from F-FDG PET/CT was the most accurate method overall.
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Introduction: Hypoglycemia is the most common acute complication in individuals with type 1 diabetes (T1D). Episodes of mild or moderate hypoglycemia should be treated in adults with a dose of around 15-20 g fast-acting carbohydrates. However, this self-treatment of hypoglycemia in real-life condition is not well documented.

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Background And Objectives: The main objective of this study was to assess the percentage of co-morbid nephropathy in type 2 diabetes patients using the CKD-EPI equation and to compare the clinical characteristics and treatments of patients with type 2 diabetes with nephropathy with those of patients without nephropathy PATIENTS AND METHODS: This was a cross-sectional analysis of the demographic and clinical data registered in the IDIBAPS Biobank database. Patients were considered to have nephropathy if the diagnosis was reported in their clinical history, albuminuria (>30 mg/g) was indicated as present in the last urine test available, or an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m was calculated using the CKD-EPI equation.

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Article Synopsis
  • * Results showed that sedentary rates were 32.3% for men and 39% for women, with key differences noted across various age groups.
  • * Sedentary individuals also exhibited higher BMI and obesity rates, and low physical activity levels were linked to increased risks of obesity and diabetes, emphasizing the need for greater awareness and intervention in Spain.
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Patients with type 1 diabetes (T1D) present increased risk of cardiovascular disease (CVD). The aim of this study is to improve the assessment of lipoprotein profile in patients with T1D by using a robust developed method 1H nuclear magnetic resonance spectroscopy (1H NMR), for further correlation with clinical factors associated to CVD. Thirty patients with T1D and 30 non-diabetes control (CT) subjects, matched for gender, age, body composition (DXA, BMI, waist/hip ratio), regular physical activity levels and cardiorespiratory capacity (VO2peak), were analyzed.

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Context: Diabetes is frequently diagnosed late, when the development of complications is almost inevitable, decreasing the quality of life of patients. However, early detection of affected individuals would allow the implementation of timely and effective therapies.

Objective: Here we set to describe the profile of circulating microRNAs (miRNAs) in prediabetic patients with the intention of identifying novel diagnostic and therapeutic tools.

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The beneficial effects of exercise in patients with type 1 diabetes (T1D) are not fully proven, given that it may occasionally induce acute metabolic disturbances. Indeed, the metabolic disturbances associated with sustained exercise may lead to worsening control unless great care is taken to adjust carbohydrate intake and insulin dosage. In this work, pre- and post-exercise metabolites were analyzed using a (1)H-NMR and GC-MS untargeted metabolomics approach assayed in serum.

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