Health-related Quality of Life and Exercise Capacity in Double Lung Transplant Recipients With Baseline Lung Allograft Dysfunction.

Background: Baseline lung allograft dysfunction (BLAD) after lung transplant is associated with an increased risk of dying, but the association with health-related quality of life (HRQL) and exercise capacity is not known. We hypothesized that BLAD would be associated with reduced HRQL and 6-min walk distance (6MWD) at 1 y post-lung transplant.

Methods: We analyzed patients who underwent lung transplants in our program from 2004 to 2018 who completed 1-y 36-item Short Form (SF-36) questionnaire and 6MWD testing.

Impact of late to moderate preterm birth on minimal pair word-learning.

Little is known about language development after late-to-moderate premature birth, the most significant part of prematurity worldwide. We examined minimal-pair word-learning skills in 18 eighteen-month-old healthy full-term (mean gestational age [GA] at birth = 39.6 weeks; 7 males; 100% Caucasian) and 18 healthy late-to-moderate preterm infants (mean GA at birth 33.

Who spoke that language? Assessing early face-language associations in monolingual and bilingual infants.

Introduction: In bilingual communities, knowing the language each speaker uses may support language separation and, later, guide language use in a context-appropriate manner. Previous research has shown that infants begin to form primary associations between the face and the language used by a speaker around the age of 3 months. However, there is still a limited understanding of how robust these associations are and whether they are influenced by the linguistic background of the infant.

Retrospective cohort study on the bilateral occurrence of invasive lobular breast cancer.

Objective: Invasive lobular carcinoma (ILC) is the second most common histological subtype of invasive breast cancer, following the no special type (NST) invasive carcinoma. It has historically been assumed that ILC occurs bilaterally in 20-29 % of cases, which has influenced the inclusion of MRI in the standard workup of ILC according to European guidelines. However, challenging this long-held belief regarding the bilateral occurrence of ILC opens up the possibility of revising the guidelines and using MRI only for more specific indications.

Literature review on the bilateral occurrence of invasive lobular breast cancer.

Historically, it has been believed that invasive lobular carcinomas (ILC) occur more frequently bilaterally compared to other invasive subtypes, with estimates ranging between 20% and 29%. This study aims to determine if this historical perspective still holds true. A comprehensive literature review was conducted to examine the bilateral occurrence of lobular carcinoma using various imaging methods.

Aerobiological and clinical study in the semidesertic area of the Southeastern of Spain.

Aerobiological studies constitute a relevant tool to predict the most influential parameters over the pollen seasons with significant clinical relevance in the allergic populations. The aim of this study was to describe the aerobiological behaviour of the most relevant allergenic sources in the semi-arid area of southeast of Spain (Almería) and to investigate the correlation with meteorological factors and clinical symptoms of allergic patients. Daily pollen count and meteorological parameters of Almería, Spain, were compiled for ten years.

Time course of attention to a talker's mouth in monolingual and close-language bilingual children.

We presented 28 Spanish monolingual and 28 Catalan-Spanish close-language bilingual 5-year-old children with a video of a talker speaking in the children's native language and a nonnative language and examined the temporal dynamics of their selective attention to the talker's eyes and mouth. When the talker spoke in the children's native language, monolinguals attended equally to the eyes and mouth throughout the trial, whereas close-language bilinguals first attended more to the mouth and then distributed attention equally between the eyes and mouth. In contrast, when the talker spoke in a nonnative language (English), both monolinguals and bilinguals initially attended more to the mouth and then gradually shifted to a pattern of equal attention to the eyes and mouth.

Connecting perception and production in early Catalan-Spanish bilingual children: language dominance and quality of input effects.

This study investigates perception and production of the Catalan mid-vowel /e/-/ɛ/ contrast by two groups of 4.5-year-old Catalan-Spanish bilingual children, differing in language dominance. Perception was assessed with an XAB discrimination task involving familiar words and non-words.

Immunomodulatory treatment of interstitial lung disease.

Interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis (IPF) have an array of immunomodulatory treatment options compared with IPF, due to their inflammatory component. However, there is a relative paucity of guidance on the management of this heterogeneous group of diseases. In ILDs other than IPF, immunosuppression is the cornerstone of therapy, with varying levels of evidence for different immunomodulatory agents and for each specific ILD.

A Retrospective, Descriptive Study of Dyspnea Management in a Multidisciplinary Interstitial Lung Disease Clinic.

Fibrotic interstitial lung diseases (F-ILDs) have a high symptom burden with progressive dyspnea as a primary feature. Breathlessness is underrecognized and undertreated primarily due to lack of consensus on how to best measure and manage it. Several nonpharmacologic and pharmacologic strategies are published in the literature, however there is a paucity of real-world data describing their systematic implementation.

Cognitive and Learning Outcomes in Late Preterm Infants at School Age: A Systematic Review.

Late preterm children born between 34 and 36 weeks' gestation account for ≈70% of prematurely born infants. There is growing concern about this population at risk of mild neurodevelopmental problems, learning disabilities and lower academic performance. Following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement, this paper analyzes recent published evidence from 16selected studies involving late preterm children and control group assessments at preschool and/or school age, mainly focusing on cognitive functioning, language learning and academic achievement.

Signatures of brain plasticity supporting language recovery after perinatal arterial ischemic stroke.

Brain imaging methods such as functional Magnetic Resonance Imaging (fMRI) and Diffusion Tensor Imaging (DTI) have already been used to decipher the functional and structural brain changes occurring during normal language development. However, little is known about the differentiation of the language network after an early lesion. While in adults, stroke over the left hemisphere generally induces post-stroke aphasia, it is not always the case when a stroke occurs in the perinatal period, thus revealing a remarkable plastic power of the language network during early development.

A Revolution by Stealth: A Legal-Ethical Analysis of the Rise of Pre-Conception Authorization of Surrogacy Agreements.

This article offers a legal-ethical analysis of recent UK and Dutch proposals to regulate surrogacy proactively through a national system of pre-conception authorization of surrogacy agreements. Within such a system, authorities are already before conception called upon to examine and assess contractual arrangements between the intending parents and the prospective surrogate mother. This regulatory approach is presented by its advocates as a for all parties involved; as bringing family law in line with the changed social reality of creating families; and as maintaining a non-permissive approach toward commercial surrogacy.

Attenuated brain responses to speech sounds in moderate preterm infants at term age.

Recent findings have revealed that very preterm neonates already show the typical brain responses to place of articulation changes in stop consonants, but data on their sensitivity to other types of phonetic changes remain scarce. Here, we examined the impact of 7-8 weeks of extra-uterine life on the automatic processing of syllables in 20 healthy moderate preterm infants (mean gestational age at birth 33 weeks) matched in maturational age with 20 full-term neonates, thus differing in their previous auditory experience. This design allows elucidating the contribution of extra-uterine auditory experience in the immature brain on the encoding of linguistically relevant speech features.

Right Structural and Functional Reorganization in Four-Year-Old Children with Perinatal Arterial Ischemic Stroke Predict Language Production.

Brain imaging methods have contributed to shed light on the mechanisms of recovery after early brain insult. The assumption that the unaffected right hemisphere can take over language functions after left perinatal stroke is still under debate. Here, we report how patterns of brain structural and functional reorganization were associated with language outcomes in a group of four-year-old children with left perinatal arterial ischemic stroke (PAIS).

Multi-Pattern Visual Statistical Learning in Monolinguals and Bilinguals.

To date, the impact of bilingualism on statistical learning remains unclear. Here we test a novel visual statistical learning task that affords simultaneous learning of two types of regularities: co-occurrence regularities between pairs of elements and the co-occurrence of visual features that could define categories. We compared performance by English monolinguals, Spanish-Catalan bilinguals and Spanish-English bilinguals, as previous studies have suggested that bilinguals might be more open than monolinguals to the presence of multiple regularities, though no previous studies have tested the learning of multiple patterns within a single task.

Twelve-month-old infants' attention to the eyes of a talking face is associated with communication and social skills.

We investigated whether attention to a talker's eyes in 12 month-old infants is related to their communication and social abilities. We measured infant attention to a talker's eyes and mouth with a Tobii eye-tracker and examined the correlation between attention to the talker's eyes and scores on the Adaptive Behavior Questionnaire from the Bayley Scales of Infant and Toddler Development (BSID-III). Results indicated a positive relationship between eye gaze and scores on the Social and Communication subscales of the BSID-III.

Inside bilingualism: Language background modulates selective attention to a talker's mouth.

Previous findings indicate that bilingual Catalan/Spanish-learning infants attend more to the highly salient audiovisual redundancy cues normally available in a talker's mouth than do monolingual infants. Presumably, greater attention to such cues renders the challenge of learning two languages easier. Spanish and Catalan are, however, rhythmically and phonologically close languages.

Measured free 25-hydroxyvitamin D in healthy children and relationship to total 25-hydroxyvitamin D, calculated free 25-hydroxyvitamin D and vitamin D binding protein.

Background: vitamin D deficiency in children is still a global health problem. Measuring free 25-hydroxyvitamin D concentrations could provide a better estimate of the vitamin D status than total 25-hydroxyvitamin D (25(OH)D) levels.

Objective: To assess the relationship between measured free vitamin D (m-f25(OH)D) and calculated free 25(OH)D (c-f25(OH)D), total 25(OH)D, intact parathyroid hormone (iPTH) and other markers of phosphocalcic metabolism.

Enhanced Neonatal Brain Responses To Sung Streams Predict Vocabulary Outcomes By Age 18 Months.

Words and melodies are some of the basic elements infants are able to extract early in life from the auditory input. Whether melodic cues contained in songs can facilitate word-form extraction immediately after birth remained unexplored. Here, we provided converging neural and computational evidence of the early benefit of melodies for language acquisition.

The Language Exposure Assessment Tool: Quantifying Language Exposure in Infants and Children.

Purpose: The aim of this study was to develop the Language Exposure Assessment Tool (LEAT) and to examine its cross-linguistic validity, reliability, and utility. The LEAT is a computerized interview-style assessment that requests parents to estimate language exposure. The LEAT yields an automatic calculation of relative language exposure and captures qualitative aspects of early language experience.

Language learning and brain reorganization in a 3.5-year-old child with left perinatal stroke revealed using structural and functional connectivity.

Brain imaging methods have contributed to shed light on the possible mechanisms of recovery and cortical reorganization after early brain insult. The idea that a functional left hemisphere is crucial for achieving a normalized pattern of language development after left perinatal stroke is still under debate. We report the case of a 3.

Bilingualism modulates infants' selective attention to the mouth of a talking face.

Infants growing up in bilingual environments succeed at learning two languages. What adaptive processes enable them to master the more complex nature of bilingual input? One possibility is that bilingual infants take greater advantage of the redundancy of the audiovisual speech that they usually experience during social interactions. Thus, we investigated whether bilingual infants' need to keep languages apart increases their attention to the mouth as a source of redundant and reliable speech cues.

Language development at 18 months is related to multimodal communicative strategies at 12 months.

The present study investigated the degree to which an infants' use of simultaneous gesture-speech combinations during controlled social interactions predicts later language development. Nineteen infants participated in a declarative pointing task involving three different social conditions: two experimental conditions (a) available, when the adult was visually attending to the infant but did not attend to the object of reference jointly with the child, and (b) unavailable, when the adult was not visually attending to neither the infant nor the object; and (c) a baseline condition, when the adult jointly engaged with the infant's object of reference. At 12 months of age measures related to infants' speech-only productions, pointing-only gestures, and simultaneous pointing-speech combinations were obtained in each of the three social conditions.

Mental health problems in undocumented and documented migrants: a survey study.

Background: Undocumented migrants (UM) frequently report mental health problems. It is unknown to what extent these migrants seek help for these problems in general practice and how these issues are explored, discussed, registered and treated by GPs.

Objective: To gain insight in the registration and treatment of mental health problems in general practice of UM compared to documented migrants (DM).