Publications by authors named "Laura Bernal Vaca"
Article Synopsis
- The study investigates the genomic characteristics of patients with metastatic prostate cancer (mPC), focusing on the genetic testing and outcomes of these patients across various centers worldwide.
- A total of 349 mPC patients from 12 academic centers in five countries were included, with 66.6% undergoing genomic analysis, primarily through multigene panel analyses and next-generation sequencing.
- The findings reveal important progression-free survival (PFS) data, particularly in the metastatic castration-resistant prostate cancer (mCRPC) group, and contribute valuable insights to the understanding of the genomic landscape of advanced prostate cancer in Latin America, which is often underrepresented in clinical trials.
Background: Comprehensive genomic profiling (CGP) identifies genetic alterations and patterns that are crucial for therapy selection and precise treatment development. In Colombia, limited access to CGP tests underscores the necessity of documenting the prevalence of treatable genetic alterations. This study aimed to describe the somatic genetic profile of specific cancer types in Colombian patients and assess its impact on treatment selection.
View Article and Find Full Text PDFPurpose: Urothelial cancer accounts for approximately 3% of new cancer cases worldwide, with a high burden of disease in countries with medium and low human development indexes where its incidence and mortality are increasing. The purpose of this consensus is to develop statements on the evaluation and treatment of locally advanced and metastatic urothelial carcinoma that would further guide the clinical practice in Latin America.
Methods: A systematic review of the literature was conducted by an independent team of methodologists.
Metastatic melanomas in the pediatric population are rare, but they have been appearing more frequently. Unfortunately, little is known about the differences in the biology and therapeutic implications of pediatric metastatic melanomas when compared to those found in adults. Herein, we have presented the case of a 13-year-old girl with a stage IIID malignant melanoma arising from a congenital nevus.
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