Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples.

In 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and resolution has increased, requiring major improvements in the capabilities of such microscopes. Here, we introduce the next-generation mesoSPIM ("Benchtop") with a significantly increased field of view, improved resolution, higher throughput, more affordable cost, and simpler assembly compared to the original version.

The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples.

In 2015, we launched the mesoSPIM initiative (www.mesospim.org), an open-source project for making light-sheet microscopy of large cleared tissues more accessible.

Dual-phase xenon time projection chambers for rare-event searches.

In the past decade, dual-phase xenon time projection chambers (Xe-TPCs) have emerged as some of the most powerful detectors in the fields of astroparticle physics and rare-event searches. Developed primarily towards the direct detection of dark matter particles, experiments presently operating deep underground have reached target masses at the multi-tonne scale, energy thresholds of approximately 1 keV and radioactivity-induced background rates similar to those from solar neutrinos. These unique properties, together with demonstrated stable operation over several years, allow for the exploration of new territory via high-sensitivity searches for a plethora of ultra-rare interactions.

A dual-phase xenon TPC for scintillation and ionisation yield measurements in liquid xenon.

A small-scale, two-phase (liquid/gas) xenon time projection chamber () was designed, constructed and is under operation at the University of Zürich. Its main purpose is to investigate the microphysics of particle interactions in liquid xenon at energies below 50 keV, which are relevant for rare event searches using xenon as target material. Here we describe in detail the detector, its associated infrastructure, and the signal identification algorithm developed for processing and analysing the data.

Direct detection constraints on superheavy dark matter.

The dark matter in the Universe might be composed of superheavy particles (mass greater, similar 10(10) GeV). These particles can be detected via nuclear recoils produced in elastic scatterings from nuclei. We estimate the observable rate of strongly interacting supermassive particles (simpzillas) in direct dark matter search experiments.