UV- and visible-light photocatalysis using Ni-Co bimetallic and monometallic hydrotalcite-like materials for enhanced CO methanation in sabatier reaction.

The CO catalytic reduction activities of four different Co-modified Ni-based catalysts derived from hydrotalcite-like materials (HTCs) prepared by co-precipitation method were investigated under thermal and photocatalytic conditions. All catalysts were tested from 473 to 723 K at 10 bar (abs). The light intensity for photocatalytic reactions was 2.

Development of High Temperature Water Sorbents Based on Zeolites, Dolomite, Lanthanum Oxide and Coke.

Methanation is gaining attention as it produces green methane from CO and H, through Power-to-Gas technology. This process could be improved by in situ water sorption. The main difficulty for this process intensification is to find effective water sorbents at useful reaction temperatures (275-400 °C).

Graphene-based versus alumina supports on CO methanation using lanthanum-promoted nickel catalysts.

The valorization of CO as a biofuel, transforming it through methanation as part of the power-to-gas (P2G) process, will allow the reduction of the net emissions of this gas to the atmosphere. Catalysts with 13 wt.% of nickel (Ni) loading incorporated into alumina and graphene derivatives were used, and the effect of the support on the activity was examined at temperatures between 498 and 773 K and 10 bar of pressure.

Correlations between the NMR Lipoprotein Profile, Genotype, and Cholesterol Efflux Capacity of Fasting Plasma from Cognitively Healthy Elderly Adults.

Cholesterol efflux capacity (CEC) is of interest given its potential relationship with several important clinical conditions including Alzheimer's disease. The inactivation of the locus in mouse models supports the idea that it is involved in determining the CEC. With that in mind, we examine the impact of the plasma metabolome profile and the genotype on the CEC in cognitively healthy elderly subjects.

Neurological Complications in Systemic Inflammatory Diseases.

Systemic inflammatory diseases could produce neurologic complications, and they are frequently incorporated in the differential diagnosis of neurological symptoms. There are wellestablished criteria to meet the diagnosis of neurologic manifestations of these systemic diseases. Methods: However, the range of clinical presentations varies in each condition, and the prevalence of these complications differs between studies.

Advances in quantum dots as diagnostic tools.

Quantum dots (QDs) are crystalline inorganic semiconductor nanoparticles a few nanometers in size that possess unique optical electronic properties vs those of larger materials. For example, QDs usually exhibit a strong and long-lived photoluminescence emission, a feature dependent on size, shape and composition. These special optoelectronic properties make them a promising alternative to conventional luminescent dyes as optical labels in biomedical applications including biomarker quantification, biomolecule targeting and molecular imaging.

Absolute quantification of proteins using element mass spectrometry and generic standards.

Elemental mass spectrometry is a powerful analytical technique widely established in inorganic analysis. However, despite its quantitative capabilities, it is not yet fully integrated or considered in Life Sciences fields like proteomics. Whereas it is true that ICP-MS has suffered from several instrumental and analytical limitations that have hindered its applicability in protein analysis, significant developments during the last decades have turned ICP-MS into an interesting and, in our opinion, a powerful tool to consider for accurate protein quantification without recourse to specific protein standards.

The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae.

Streptococcus pneumoniae is a natural colonizer of the human respiratory tract and an opportunistic pathogen. Although epithelial cells are among the first to encounter pneumococci, the cellular processes and contribution of epithelial cells to the host response are poorly understood. Here, we show that a S.

Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection.

The enteroinvasive bacterium Shigella flexneri forces its uptake into non-phagocytic host cells through the translocation of T3SS effectors that subvert the actin cytoskeleton. Here, we report de novo actin polymerization after cellular entry around the bacterium-containing vacuole (BCV) leading to the formation of a dynamic actin cocoon. This cocoon is thicker than any described cellular actin structure and functions as a gatekeeper for the cytosolic access of the pathogen.

A study of deactivation by HS and regeneration of a Ni catalyst supported on AlO, during methanation of CO. Effect of the promoters Co, Cr, Fe and Mo.

Energy storage from renewable sources is possible by chemical procedures, power to gas technology being a possible solution for long-term storage. In this work, CO methanation from a sulphur containing gas was studied, taking into account deactivation of the catalysts and a regeneration process. In order to improve the sulphur resistance of a standard nickel (13%) catalyst supported on alumina, transition metals like molybdenum (Mo), iron (Fe), cobalt (Co) or chromium (Cr), in different proportions (from 4 to 8 wt%) were added to the catalyst formulation.

Heterogeneous Catalyzed Thermochemical Conversion of Lignin Model Compounds: An Overview.

Thermochemical lignin conversion processes can be described as complex reaction networks involving not only de-polymerization and re-polymerization reactions, but also chemical transformations of the depolymerized mono-, di-, and oligomeric compounds. They typically result in a product mixture consisting of a gaseous, liquid (i.e.

Multicatalysis Combining 3D-Printed Devices and Magnetic Nanoparticles in One-Pot Reactions: Steps Forward in Compartmentation and Recyclability of Catalysts.

A tricatalytic compartmentalized system that immobilizes metallic species to perform one-pot sequential functionalization is described: a three-dimensional (3D)-printed palladium monolith, ferritic copper(I) magnetic nanoparticles, and a 3D-printed polypropylene capsule-containing copper(II) loaded onto polystyrene-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene (PS-TBD) allowed the rapid synthesis of diverse substituted 1-([1,1'-biphenyl]-4-yl)-1-1,2,3-triazoles.

Renal control of disease tolerance to malaria.

Malaria, the disease caused by spp. infection, remains a major global cause of morbidity and mortality. Host protection from malaria relies on immune-driven resistance mechanisms that kill However, these mechanisms are not sufficient per se to avoid the development of severe forms of disease.

Enhanced, robust light-driven H generation by gallium-doped titania nanoparticles.

The splitting of water into molecular hydrogen and oxygen with the use of renewable solar energy is considered one of the most promising routes to yield sustainable fuel. Herein, we report the H evolution performance of gallium doped TiO photocatalysts with varying degrees of Ga dopant. The gallium(iii) ions induced significant changes in the structural, textural and electronic properties of TiO nanoparticles, resulting in remarkably enhanced photocatalytic activity and good stability for H production.

Metabolic Adaptation Establishes Disease Tolerance to Sepsis.

Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses to infection, compromising host homeostasis. Disease tolerance is a defense strategy against infection that preserves host homeostasis without exerting a direct negative impact on pathogens. Here, we demonstrate that induction of the iron-sequestering ferritin H chain (FTH) in response to polymicrobial infections is critical to establish disease tolerance to sepsis.

Novel Multitarget Hybrid Compounds for the Treatment of Alzheimer's Disease.

Alzheimer's disease (AD) is the most prevalent among the aging diseases known as neurodegenerative disorders. Drug design programs over the last two decades were mainly based on the cholinergic, the amyloid or the tau hypothesis. However, none of the new drugs have a real impact on the outcome of the disease.

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.

NKX2 homeobox family proteins have a role in cancer development. Here we show that NKX2-3 is overexpressed in tumour cells from a subset of patients with marginal-zone lymphomas, but not with other B-cell malignancies. While Nkx2-3-deficient mice exhibit the absence of marginal-zone B cells, transgenic mice with expression of NKX2-3 in B cells show marginal-zone expansion that leads to the development of tumours, faithfully recapitulating the principal clinical and biological features of human marginal-zone lymphomas.

Production of anti-LPS IgM by B1a B cells depends on IL-1β and is protective against lung infection with Francisella tularensis LVS.

The role of IL-1β and IL-18 during lung infection with the gram-negative bacterium Francisella tularensis LVS has not been characterized in detail. Here, using a mouse model of pneumonic tularemia, we show that both cytokines are protective, but through different mechanisms. Il-18-/- mice quickly succumb to the infection and showed higher bacterial burden in organs and lower level of IFNγ in BALF and serum compared to wild type C57BL/6J mice.

Human adipose tissue-derived mesenchymal stromal cells promote B-cell motility and chemoattraction.

Background Aims: Mesenchymal stromal cells hold special interest for cell-based therapy because of their tissue-regenerative and immunosuppressive abilities. B-cell involvement in chronic inflammatory and autoimmune pathologies makes them a desirable target for cell-based therapy. Mesenchymal stromal cells are able to regulate B-cell function; although the mechanisms are little known, they imply cell-to-cell contact.

Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.

Two distinct defense strategies can protect the host from infection: resistance is the ability to destroy the infectious agent, and tolerance is the ability to withstand infection by minimizing the negative impact it has on the host's health without directly affecting pathogen burden. Burkholderia pseudomallei is a Gram-negative bacterium that infects macrophages and causes melioidosis. We have recently shown that inflammasome-triggered pyroptosis and IL-18 are equally important for resistance to B.

ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease.

The neuroprotective profile of the dibenzothiadiazepine ITH12410/SC058 (2-chloro-5,6-dihydro-5,6-diacetyldibenzo[b,f][1,4,5]thiadiazepine) against several neurotoxicity models related to neurodegenerative diseases is herein described. ITH12410/SC058 protected SH-SY5Y cells against the loss of cell viability elicited by amyloid beta peptide and okadaic acid, a selective inhibitor of phosphoprotein phosphatase 2A that induces neurofibrillary tangle formation. Furthermore, ITH12410/SC058 is neuroprotective against several in vitro models of oxidative stress, that is, H2O2 exposure or incubation with rotenone plus oligomycin A in SH-SY5Y cells, and oxygen and glucose deprivation followed by reoxygenation in rat hippocampal slices.

TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases.

B cells use a plethora of TLR to recognize pathogen-derived ligands. These innate signals have an important function in the B cell adaptive immune response and modify their trafficking and tissue location. The direct role of TLR signaling on B cell dynamics nonetheless remains almost entirely unknown.