Comparison of Three Chemotherapy Protocols With Electrochemotherapy for the Treatment of Feline Cutaneous Squamous Cell Carcinoma.

Electrochemotherapy (ECT) with intravenous (IV) and/or intratumoral (IT) bleomycin has shown considerable efficacy in the treatment of non-resectable feline cutaneous squamous cell carcinoma (cSCC), boasting response rates of up to 95%, but other chemotherapy protocols have not yet been investigated. The objective of this prospective multicentre study was to compare the overall response rate (ORR) and progression-free interval (PFI) between cats with cSCC treated with ECT using IT and IV carboplatin (IV + IT), IV carboplatin (IV) or IV bleomycin (IV). A total of 44 cats with unresectable cSCC across three centres were enrolled and treated with ECT using carboplatin IV + IT (n = 10), carboplatin IV (n = 11) or bleomycin IV (n = 23).

High-contrast coercive field engineering for periodic poling of RbKTiOPO with Ba/K ion-exchange.

We investigate a new method of coercive field engineering for periodic poling of RbKTiOPO (RKTP). By ion exchanging RKTP in a molten salt containing 7 mol% Ba(NO) and 93 mol% KNO we achieve more than an order of magnitude difference in polarization switching time between the exchanged and non-exchanged regions. This method is used to fabricate periodic gratings of 2.

Hashimoto's Encephalopathy with Use of Intravenous Immunoglobulin as First-Line Therapy.

Hashimoto's encephalopathy is an uncommon cause of altered mental status in hospitalized patients and is challenging to diagnose, particularly in the presence of other psychiatric comorbidities. Corticosteroids are the primary treatment. Here, we present a patient with history of post-traumatic stress disorder and prior substance abuse admitted with profound altered mental status and agitation requiring admission to the intensive care unit and mechanical ventilation.

Performance of the FreeStyle Libre Flash Glucose Monitoring System during an Oral Glucose Tolerance Test and Exercise in Healthy Adolescents.

This study's aim was to assess FreeStyle Libre Flash glucose monitoring (FGM) performance during an oral glucose tolerance test (OGTT) and treadmill exercise in healthy adolescents. This should advance the feasibility and utility of user-friendly technologies for metabolic assessments in adolescents. Seventeen healthy adolescents (nine girls aged 12.

Rapid Vital Sign Extraction for Real-Time Opto-Physiological Monitoring at Varying Physical Activity Intensity Levels.

Robustness of physiological parameters obtained from photoplethysmographic (PPG) signals is highly dependent on a signal quality that is often affected by the motion artefacts (MAs) generated during physical activity. This study aims to suppress MAs and obtain reliable physiological readings using the part of the pulsatile signal, captured by a multi-wavelength illumination optoelectronic patch sensor (mOEPS), that minimizes the residual between the measured signal and the motion estimates obtained from an accelerometer. The minimum residual (MR) method requires the simultaneous collection of (1) multiple wavelength data from the mOEPS, and (2) motion reference signals from a triaxial accelerometer attached to the mOEPS.

Understanding parent experiences of end-of-life care for children: A systematic review and qualitative evidence synthesis.

Background: An estimated 21 million children worldwide would benefit from palliative care input and over 7 million die each year. For parents of these children this is an intensely emotional and painful time through which they will need support. There is a lack of synthesised research about how parents experience the care delivered to their child at the end of life.

Breaking Sitting Time with Physical Activity Increases Energy Expenditure but Does Not Alter Postprandial Metabolism in Girls.

Purpose: Young people spend a substantial proportion of their time at school sedentary; therefore, this setting represents an important target for interventions aimed at displacing sedentary time with physical activity. This study aimed to examine the postprandial metabolic effects of breaking sedentary time by accumulating walking and repeated bouts of nonambulatory standing during simulated school days in inactive adolescent girls.

Methods: Seventeen girls (mean ± SD = 12.

Assessing the use of prescription drugs and dietary supplements in obese respondents in the National Health and Nutrition Examination Survey.

Introduction: Obesity is a common disease and a known risk factor for many other conditions such as hypertension, type 2 diabetes, and cancer. Treatment options for obesity include lifestyle changes, pharmacotherapy, and surgical interventions such as bariatric surgery. In this study, we examine the use of prescription drugs and dietary supplements by the individuals with obesity.

Intra-cavity dark pulse generation through synchronized sum-frequency mixing.

A Nd:YVO laser operating at 1064 nm generating a stable mode-locked train of 10 ps-long dark pulses with a 211 MHz repetition rate is presented. The mode-locking relies on a periodic loss modulation produced by intra-cavity sum-frequency mixing with a synchronous bright-pulse train from a mode-locked femtosecond Yb:KYW laser at 1040 nm. A modulation depth of 90% was achieved for the dark pulses, confirmed by cross-correlation measurements.

Room temperature photon-counting lidar at 3 µm.

A midinfrared single-photon-counting lidar at 3 µm is presented. The 3 µm photons were upconverted to 790 nm in a periodically poled rubidium-doped crystal through intracavity mixing inside a 1064 nm : laser and detected using a conventional silicon single-photon avalanche detector (SPAD). The lidar system could distinguish 1 mm deep features on a diffusely reflecting target, limited by the SPAD and time-tagging electronics.

Effect of Changing Match Format from Halves to Quarters on the Performance Characteristics of Male University Field Hockey Players.

The study examined whether the performance characteristics of male university field hockey players differed when the match format was 2 × 35 min halves compared to 2 × 2 × 17.5 min quarters. Thirty-five male university field hockey players (age 21.

Assessing the Use and Perception of Dietary Supplements Among Obese Patients with National Health and Nutrition Examination Survey.

Complementary alternative medicine, especially dietary supplements (DS), has gained increasing popularity for weight loss due to its availability without prescription, price, and ease of use. Besides weight loss, there are various perceived, potential benefits linked to DS use. However, health consumers with limited health literacy may not adequately know the benefits and risk of overdose for DS.

Exploring the Discrepancies in Actual and Perceived Benefits of Dietary Supplements Among Obese Patients.

Dietary supplements (DSs) have gained increased popularity for weight loss due to its availability without prescription, relatively low price, and ease of use. Consumers with limited health literacy may not adequately know the benefits and risks associated with DSs. In this project, we found a knowledge gap between reported benefits of major DSs by adults with obesity in the National Health and Nutrition Examination Survey 2003-2014 and those reported in existing DS knowledge databases.

Enhancing Prediction Models for One-Year Mortality in Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome.

Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built computational models to predict one-year mortality of patients admitted to an intensive care unit (ICU) with AMI or post myocardial infarction syndrome. Our prior work only used the structured clinical data from MIMIC-III, a publicly available ICU clinical database.

Safety and toxicity of combined oclacitinib and carboplatin or doxorubicin in dogs with solid tumors: a pilot study.

Background: Oclacitinib is an orally bioavailable Janus Kinase (JAK) inhibitor approved for the treatment of canine atopic dermatitis. Aberrant JAK/ Signal Transducer and Activator of Transcription (STAT) signaling within hematologic and solid tumors has been implicated as a driver of tumor growth through effects on the local microenvironment, enhancing angiogenesis, immune suppression, among others. A combination of JAK/STAT inhibition with cytotoxic chemotherapy may therefore result in synergistic anti-cancer activity, however there is concern for enhanced toxicities.

Short Sprints Accumulated at School Modulate Postprandial Metabolism in Boys.

Introduction: This study examined the efficacy of maximal sprint running accumulated during a typical school day to modulate postprandial metabolism in adolescent boys.

Methods: Nineteen adolescent boys completed three 2-d experimental conditions: a standard-practice control (CON), an accumulated in-school sprint running (ACC), and a single block of afterschool sprint running (BLO). On day 1, a fasting capillary blood sample was taken at 0735 h in the school.

Building Computational Models to Predict One-Year Mortality in ICU Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome.

Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be utilized to save time and improve prediction accuracy. This study built and evaluated various machine learning models to predict one-year mortality in patients diagnosed with acute myocardial infarction or post myocardial infarction syndrome in the MIMIC-III database.

Reliability of a Novel Badminton Intermittent Exercise Protocol.

: Badminton is a sport characterized by high-intensity activity interspersed with short rests requiring specific physiological fitness, skills and game tactics. This study aimed to develop, describe and establish the reliability of a novel badminton intermittent exercise protocol, to simulate singles match-play (Part A) and assess match-fitness (Part B). : Twelve well-trained male badminton players performed a two-part protocol, mimicking the demands and activity of match-play, on two occasions with at least 72-h recovery.