Publications by authors named "Laura Barahona"
Article Synopsis
- Dihydromyricetin has great pharmaceutical potential but is limited by poor solubility and stability, prompting the synthesis of glucosides to enhance its bioavailability.
- Through the use of a specific sucrose phosphorylase variant, researchers developed three monoglucosides, with dihydromyricetin 4'--α-D-glucopyranoside being the most prevalent.
- Acylation of this monoglucoside created three novel derivatives, and studies showed that modifications in their structure impacted both water solubility and antioxidant activity.
Article Synopsis
- The study focused on the prevalence of anticoagulant resistance genotypes in brown rats (Rattus norvegicus) and black rats (Rattus rattus) in Barcelona, assessing the impact of control methods involving rodenticides.
- Sampling occurred during periods when different anticoagulant rodenticides were used, revealing no evidence of resistance in the rats based on genetic analysis of the Vkorc1 gene.
- The findings suggest that the current rodent management practices, including rotating anticoagulants and using traps, are effective in preventing resistance; however, future efforts should expand the variety of control measures used.
Article Synopsis
- Human activities, such as deforestation and urbanization, increase the risk of zoonotic diseases by creating conducive environments for wildlife like rodents and wild boar, which can carry infectious agents like coronaviruses.
- A study in Catalonia during the COVID-19 pandemic tested over 500 animals, including rodents and wild boar, for SARS-CoV-2, finding that the majority were negative, indicating low levels of infection.
- The findings suggest that rodents and wild boar played a negligible role in the transmission of COVID-19 in the area, but ongoing surveillance is necessary due to their proximity to humans and the potential for viral mutations.
Control of rodent populations is a big challenge because of the rapid evolution of resistance to commonly used rodenticides and the collateral negative impacts that these products may have on biodiversity. Second-generation anticoagulants are very efficient but different single nucleotide polymorphisms (SNPs) in the Vkorc1 gene may confer resistance in rodents. We sequenced exons 1, 2 and 3 of the Vkorc1 gene from 111 mice (Mus musculus domesticus) captured across the city of Barcelona and found SNPs associated with resistance to first- and second-generation anticoagulants in all of them.
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