Metabolic disturbances in children with narcolepsy: a retrospective study.

Study Objectives: To determine the prevalence of metabolic syndrome (MS) in children with narcolepsy and to evaluate their clinical and sleep characteristics according to the different components of MS.

Methods: This retrospective study consisted of 58 de novo children with narcolepsy (median age: 12.7 years, 48.

Obesity in children with narcolepsy: metabolic and endocrine comorbidities.

Study Objectives: Narcolepsy with cataplexy is associated with obesity in children. We proposed to assess whether metabolic complications were linked to narcolepsy regardless of obesity. The second aim of the study was to compare endocrine comorbidities in obese children with narcolepsy and control patients.

Characterization of rapid weight gain phenotype in children with narcolepsy.

Objectives: To characterize the rapid weight gain (RWG) phenotype associated with the onset of childhood narcolepsy and to determine whether it could constitute a marker of severity of the disease.

Methods: RWG was defined using the BMI z-score slope reported to one year (>0.67 SD) from symptom onset to disease diagnosis.