Publications by authors named "Laura Armengol Debeir"
Background: The management of Crohn's disease patients with perianal lesions and anti-TNF failure is challenging.
Aims: To assess the effectiveness of vedolizumab in perianal Crohn's disease and the predictors of success in a real-life cohort.
Methods: We conducted a nationwide multicentre cohort study in patients with perianal Crohn's disease who received vedolizumab.
Background: Fructose malabsorption may trigger gastrointestinal symptoms in irritable bowel syndrome patients and a low fructose diet seems to improve digestive symptoms.
Aim: The aim of our study was to determine whether fructose malabsorption detected by a 25g fructose breath test could be a predictor of the efficacy of a low fructose diet.
Methods: 88 patients (73 women, median age, 45.
Background: The long-term management of perianal Crohn's disease for patients on anti-TNF-α therapy remains challenging.
Aim: To evaluate the long-term course and complications of patients with perianal fistulas treated with anti-TNF-α based on their clinical remission and healing on MRI.
Methods: Patients were evaluated clinically and by MRI.
Background: Extraintestinal manifestations (EIM) have been associated with more severe course of inflammatory bowel disease. The aim was to study the frequency of EIM in pediatric- and elderly-onset Crohn's disease (CD) and the factors associated with EIM and their impact on long-term disease outcome.
Methods: Pediatric- (age at diagnosis younger than 17 years) and elderly-onset CD patients (age at diagnosis 60 years or older) from a prospective population-based registry (EPIMAD) were recruited.
Background: Recent population-based study of elderly-onset Crohn's disease patients reported age-related differences in disease phenotype and outcome.
Aims: The aim was to assess the impact of age at diagnosis on natural history of elderly-onset ulcerative colitis patients with emphasis on disease presentation, phenotype and treatment.
Methods: Elderly-onset patients with ulcerative colitis (≥60 years at diagnosis) registered in a French population-based Registry EPIMAD (1988-2006) were included.
Background And Aims: Data on extra-intestinal manifestations [EIM] and their impact on the disease course of ulcerative colitis [UC] in population-based cohorts are scarce, particularly in paediatric- and elderly-onset UC patients. The aims of this population-based study were to assess: 1] the occurrence of EIM in paediatric- and elderly-onset UC; 2] the factors associated with EIM; and 3] their impact on long-term disease outcome.
Methods: Paediatric-onset [< 17 years at diagnosis] and elderly-onset UC patients [> 60 years at diagnosis] from a French prospective population-based registry [EPIMAD] were included.
Objectives: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period.
Methods: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011.
Aim: To evaluate the imaging course of Crohn's disease (CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor (TNF)-α therapy and identify predictors of deep remission.
Methods: All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging (MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after.
We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ERBB2/17q and STK6/20q, were detected using a quantitative multiplex polymerase chain reaction of short fluorescent fragment (QMPSF) method.
View Article and Find Full Text PDFBackground & Aims: Home parenteral nutrition (HPN) improves survival and quality of life in patients with chronic intestinal failure (IF). Few cases of pregnancy on HPN have been published. The aim of this study was to report pregnancy cases on long-term HPN in benign IF.
View Article and Find Full Text PDFArticle Synopsis
- Elderly onset Crohn's disease (CD) is more favorable when diagnosed after age 70, prompting a comparison between patients diagnosed at 60-69 years and those over 70 years old.
- The study analyzed 370 patients, finding that while clinical presentation was similar, older patients had a higher frequency of pure colonic disease and a lower proportion of males.
- No significant differences were noted in disease progression or treatment patterns between the two age groups, suggesting similar challenges regardless of the age at which CD was diagnosed.
Article Synopsis
- The study analyzed postoperative complications (POCs) in children with inflammatory bowel disease, focusing on those who had major abdominal surgery.
- A total of 49.7% of patients experienced at least one POC, with a significant number of complications occurring early, particularly in patients with ulcerative colitis (UC).
- The findings highlight that while both Crohn's disease (CD) and UC have risks for late complications, only UC showed a significantly higher risk for early complications after surgery.
Background: Colorectal segmental resection is performed worldwide in a majority of women presenting with symptomatic deep endometriosis infiltrating the rectum. The aim of the present study was to investigate the pathophysiological mechanisms involved in post-operative digestive dysfunction.
Methods: We selected patients managed by colorectal resection for rectal endometriosis, who had developed post-operative severe constipation and whose follow up was superior to 24 months.