Publications by authors named "Laura Anh Nguyen"
Article Synopsis
- * In cycling cells, SAMHD1 is phosphorylated at a specific site (T592), which prevents it from blocking retroviral infections, but this phosphorylation does not impact its dNTP-depleting function.
- * The phosphorylation of SAMHD1 at T592 is regulated by cyclin-dependent kinase 1 (cdk1), indicating that this modification plays a crucial role in its antiviral capabilities.
Background: Interferon-α (IFN-α) is an essential mediator of the antiviral response, which potently inhibits both early and late phases of HIV replication. The SAMHD1 deoxynucleoside triphosphate (dNTP) hydrolase represents the prototype of a new antiviral strategy we referred to as "nucleotide depletion". SAMHD1 depletes dNTP levels in myeloid cells below those required for optimal synthesis of HIV viral DNA.
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