Publications by authors named "Laura Andessner-Angleitner"
Epigenetics Chromatin
November 2023
Article Synopsis
- During early mammalian development, DNA methylation undergoes two reprogramming waves, with the first occurring in oocytes; DNMT3A and DNMT3L are crucial for this process, but DNMT3L is not found in humans.
- Analysis of RNA-seq data from various mammals showed that Dnmt3l is expressed mainly in specific rodent species (like mice and rats) and not universally across mammals, indicating the mechanisms are not the same.
- Results suggest that DNMT3L's role in DNA methylation is limited to a few rodents and that inactive isoforms of DNMT3B, which interact with DNMT3A in somatic cells, are absent in oocytes of the
