Publications by authors named "Laura Alonso Garcia"
Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy. In the last few years, after the publication of the consensus guidelines, with refined diagnostic criteria and improved awareness, FPIES is diagnosed with increased frequency. However, despite having a background of immune dysregulation, this complication has just been described once in the posttransplant setting, in an adult patient.
View Article and Find Full Text PDFTransplantation-associated thrombotic microangiopathy (TA-TMA) is associated with high morbidity and mortality. Although survival has improved significantly with the introduction of eculizumab, the need for improvement remains, especially in high-risk patients. This study aimed to describe the results obtained with eculizumab in a pediatric cohort with the attempt to define which risk factors could determine the response to treatment.
View Article and Find Full Text PDFArticle Synopsis
- Hematopoietic stem cell transplantation (HCT) is an effective treatment for chronic granulomatous disease (CGD) in children, but it carries risks of complications and varying benefits depending on donor type.
- A study of 30 pediatric patients showed a graft failure rate of 28.26% and chronic graft-versus-host disease (GVHD) in 20.5%, with higher risks for those who received transplants from unrelated donors compared to sibling donors.
- Overall, the 2-year overall survival rate was 77.3%, but careful consideration of donor type and post-transplant care is crucial due to the potential for significant morbidity and mortality.