Publications by authors named "Laura Alejandra Lopez-Campa"
Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity.
Tannya Karen Castro-Jiménez Laura Cristina Gómez-Legorreta Laura Alejandra López-Campa Valeria Martínez-Torres Marcos Alvarado-Silva
Front Cell Infect Microbiol
July 2022
Article Synopsis
- Dengue and Zika viruses circulate in Mexico and cause annual outbreaks with varying severity, indicating ongoing selection for different virus variants.
- Researchers studied blood samples from patients in Oaxaca during 2016 and 2019 to see if different virus variants were present during outbreaks.
- They found that the ability of the viruses to withstand type I interferon antiviral responses and the accumulation of certain RNA in infected cells are linked to disease severity and certain blood conditions.